Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6810 |
| PDBID: | 4FFV |
| Chains: | HL_A |
| Organism: | Rattus norvegicus, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.40 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | 11A19 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Dipeptidyl peptidase 4 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >4FFV_H|Chain D, F[auth H]|11A19 Fab heavy chain|Mus musculus (10090) EFQLQQSGPELVKPGASVKISCKASGYSFTDYNINWMKQSNGKSLEWIGVVIPKYGTTNYNQKFQGKATLTVDQSSSTAYIQLNSLTSEDSAVYYCTRFRDVFFDVWGTGTTVTVSSAKTTAPSVYPLAPVCGGTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPALLQSGLYTLSSSVTVTSNTWPSQTITCNVAHPASSTKVDKKIVPR |
Light Chain: L
Mutation: NULL
| >4FFV_L|Chain C, E[auth L]|11A19 Fab light chain|Mus musculus (10090) QIVLSQSPAILSASPGEKVTMTCRASSSVNNMHWYQQKPGSSPKPWLHGTSNLASGVPVRFSGSGSGTSFSLTISRVEAEDAATYFCQQWSNHPPTFGGGTKLEIDRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNR |
Antigen
Chain: A
Mutation: NULL
| >4FFV_A|Chain A, B|Dipeptidyl peptidase 4|Rattus norvegicus (10116) RRTYTLADYLKNTFRVKSYSLRWVSDSEYLYKQENNILLFNAEHGNSSIFLENSTFEIFGDSISDYSVSPDRLFVLLEYNYVKQWRHSYTASYSIYDLNKRQLITEEKIPNNTQWITWSQEGHKLAYVWKNDIYVKIEPHLPSHRITSTGKENVIFNGINDWVYEEEIFGAYSALWWSPNGTFLAYAQFNDTGVPLIEYSFYSDESLQYPKTVWIPYPKAGAVNPTVKFFIVNTDSLSSTTTTIPMQITAPASVTTGDHYLCDVAWVSEDRISLQWLRRIQNYSVMAICDYDKTTLVWNCPTTQEHIETSATGWCGRFRPAEPHFTSDGSSFYKIVSDKDGYKHICQFQKDRKPEQVCTFITKGAWEVISIEALTSDYLYYISNEYKEMPGGRNLYKIQLTDHTNKKCLSCDLNPERCQYYSVSLSKEAKYYQLGCRGPGLPLYTLHRSTDQKELRVLEDNSALDKMLQDVQMPSKKLDFIVLNETRFWYQMILPPHFDKSKKYPLLIDVYAGPCSQKADAAFRLNWATYLASTENIIVASFDGRGSGYQGDKIMHAINKRLGTLEVEDQIEAARQFLKMGFVDSKRVAIWGWSYGGYVTSMVLGSGSGVFKCGIAVAPVSRWEYYDSVYTERYMGLPTPEDNLDHYRNSTVMSRAENFKQVEYLLIHGTADDNVHFQQSAQISKALVDAGVDFQAMWYTDEDHGIASSTAHQHIYSHMSHFLQQCFSLR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: ARG24 ASN30 ASN31 HIS33 SER66 THR68 TRP90 SER91 ASN92 HIS93 H: ASP31 TYR32 ASN33 ASN35 VAL50 ILE52 LYS54 TYR55 GLY56 THR57 THR58 ASN59 TYR60 GLN62 GLN65 PHE99 ASP101 A: ILE86 GLU89 ASN90 SER91 THR92 GLU94 ILE95 PHE96 GLY97 ASP98 SER99 TYR116 ASN117 VAL119 TYR133 ARG138 GLN139 LEU140 THR142 LYS145 ASP241 SER243 THR747 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
