Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6804 |
| PDBID: | 4F15 |
| Chains: | EF_D |
| Organism: | Influenza A virus (A/Korea/01/2009(H1N1)), Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.81 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | 4F15 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H1N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: E
Mutation: NULL
| >4F15_E|Chain B, E, H, K|Fab fragment, heavy chain|Mus musculus (10090) VKLQESGAVVQPGGSLRLSCAASGFTGSDYDMSWIRQAPGKGLEWVSGILGGSERSYYRDSVKGRSTISRDNSRKTLYLEMNSLRAEDTAVYYCARHSWGAYVQYGMDGWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSSVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKSC |
Light Chain: F
Mutation: NULL
| >4F15_F|Chain C, F, I, L|Fab fragment, light chain|Mus musculus (10090) DIQMTQSPASLAVSPGQRATITCRASESVSNYGINFINWFQQKPGQPPKLLIYTASNKGTGVPARFSGSGSGTDFTLTINPVEAEDTANYFCQQTKEVPYGTFGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: D
Mutation: NULL
| >4F15_D|Chain A, D, G, J|Hemagglutinin|Influenza A virus (644289) ADPGYLLEFDTLCIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDKHNGKLCKLRGVAPLHLGKCNIAGWILGNPECESLSTASSWSYIVETSSSDNGTCYPGDFIDYEELREQLSSVSSFERFEIFPKTSSWPNHDSNKGVTAACPHAGAKSFYKNLIWLVKKGNSYPKLSKSYINDKGKEVLVLWGIHHPSTSADQQSLYQNADAYVFVGSSRYSKKFKPEIAIRPKVRDQEGRMNYYWTLVEPGDKITFEATGNLVVPRYAFAMERNAGSGIIISDTPVHDCNTTCQTPKGAINTSLPFQNIHPITIGKCPKYVKSTKLRLATGLRNVPSIQSRGLFGAIAGFIEGGWTGMVDGWYGYHHQNEQGSGYAADLKSTQNAIDEITNKVNSVIEKMNTQFTAVGKEFNHLEKRIENLNKKVDDGFLDIWTYNAELLVLLENERTLDYHDSNVKNLYEKVRSQLKNNAKEIGNGCFEFYHKCDNTCMESVKNGTYDYPKYSEEAKLNREEIDGVRSLVPR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| E: ASP30 LEU51 GLY53 SER54 ARG56 SER57 TYR58 TYR59 LYS64 TRP100 GLY101 F: GLN2 GLU26 SER27 VAL28 ASN34 SER70 GLY71 GLU96 VAL97 PRO98 TYR99 D: GLU68 THR72 GLU112 ARG113 PHE114 GLU115 ILE116 PHE117 PRO118 THR120 SER121 SER122 LYS146 SER162 LYS163 SER164 ILE166 ASP168 LYS169 ARG252 TYR253 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
