Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6802 |
| PDBID: | 4F15 |
| Chains: | KL_J |
| Organism: | Influenza A virus (A/Korea/01/2009(H1N1)), Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.81 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | 4F15 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H1N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: K
Mutation: NULL
| >4F15_K|Chain B, E, H, K|Fab fragment, heavy chain|Mus musculus (10090) VKLQESGAVVQPGGSLRLSCAASGFTGSDYDMSWIRQAPGKGLEWVSGILGGSERSYYRDSVKGRSTISRDNSRKTLYLEMNSLRAEDTAVYYCARHSWGAYVQYGMDGWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSSVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKSC |
Light Chain: L
Mutation: NULL
| >4F15_L|Chain C, F, I, L|Fab fragment, light chain|Mus musculus (10090) DIQMTQSPASLAVSPGQRATITCRASESVSNYGINFINWFQQKPGQPPKLLIYTASNKGTGVPARFSGSGSGTDFTLTINPVEAEDTANYFCQQTKEVPYGTFGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: J
Mutation: NULL
| >4F15_J|Chain A, D, G, J|Hemagglutinin|Influenza A virus (644289) ADPGYLLEFDTLCIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDKHNGKLCKLRGVAPLHLGKCNIAGWILGNPECESLSTASSWSYIVETSSSDNGTCYPGDFIDYEELREQLSSVSSFERFEIFPKTSSWPNHDSNKGVTAACPHAGAKSFYKNLIWLVKKGNSYPKLSKSYINDKGKEVLVLWGIHHPSTSADQQSLYQNADAYVFVGSSRYSKKFKPEIAIRPKVRDQEGRMNYYWTLVEPGDKITFEATGNLVVPRYAFAMERNAGSGIIISDTPVHDCNTTCQTPKGAINTSLPFQNIHPITIGKCPKYVKSTKLRLATGLRNVPSIQSRGLFGAIAGFIEGGWTGMVDGWYGYHHQNEQGSGYAADLKSTQNAIDEITNKVNSVIEKMNTQFTAVGKEFNHLEKRIENLNKKVDDGFLDIWTYNAELLVLLENERTLDYHDSNVKNLYEKVRSQLKNNAKEIGNGCFEFYHKCDNTCMESVKNGTYDYPKYSEEAKLNREEIDGVRSLVPR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| K: ASP30 TRP46 GLY53 SER54 ARG56 SER57 TYR58 TYR59 ASP61 LYS64 L: GLU26 SER27 VAL28 SER29 ASN34 SER70 GLY71 GLU96 VAL97 PRO98 TYR99 J: GLU68 THR72 ALA73 GLU112 ARG113 PHE114 GLU115 ILE116 PHE117 PRO118 LYS119 THR120 SER121 SER122 LYS146 LYS163 SER164 TYR165 ILE166 ASP168 ARG252 TYR253 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
