Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 679 |
| PDBID: | 3UZV |
| Chains: | B_A |
| Organism: | Dengue virus 2 Jamaica/1409/1983, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.10 |
| Reference: | 10.1016/j.str.2012.01.001 |
| Antibody | |
| Antibody: | 4E11 scFv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | dengue virus serotype 2 envelope protein domain III |
| Antigen mutation: | No |
| Durg Target: | P12823; P27914; |
Sequence information
Antibody
Chain: B
Mutation: NULL
| >3UZV_B|Chain B|anti-dengue Mab 4E11|Mus musculus (10090) EVKLLEQSGAELVKPGASVRLSCTASGFNIKDTYMSWVKQRPEQGLEWIGRIDPANGDTKYDPKFQGKATITADTSSNTAYLHLSSLTSGDTAVYYCSRGWEGFAYWGQGTLVTVSAGGGGSGGGGSGGGGSELVMTQTPASLAVSLGQRATISCRASENVDRYGNSFMHWYQQKAGQPPKLLIYRASNLESGIPARFSGSGSRTDFTLTINPVEADDVATYFCQRSNEVPWTFGGGTKLEIKRPLEHHHHHH |
Antigen
Chain: A
Mutation: NULL
| >3UZV_A|Chain A|envelope protein|Dengue virus 2 (11064) MGMSYSMCTGKFKIVKEIAETQHGTIVIRVQYEGDGSPCKIPFEIMDLEKRHVLGRLITVNPIVTEKDSPVNIEAEPPFGDSYIIIGVEPGQLKLNWFKKGSSIGQLEHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition B: LYS3 GLY27 PHE28 LYS31 ASP32 THR33 TYR34 ARG51 ASP53 ALA55 ARG99 TRP101 GLU102 GLY103 ALA105 TYR106 ARG163 TYR164 GLY165 ASN166 PHE168 LEU182 TYR185 ARG186 ASN189 LEU190 GLU191 SER192 A: LYS305 PHE306 LYS307 ILE308 VAL309 LYS310 GLU311 ILE312 ARG323 GLN325 GLU327 GLU360 LYS361 ASP362 SER363 PRO364 GLY385 GLN386 LEU387 LYS388 LEU389 ASN390 TRP391 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
