Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6788 |
| PDBID: | 4DGI |
| Chains: | HL_A |
| Organism: | Homo sapiens, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.40 |
| Reference: | 10.1107/S0907444912037328 |
| Antibody | |
| Antibody: | POM1 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Cellular prion protein PrP(c) |
| Antigen mutation: | No |
| Durg Target: | P04156 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >4DGI_H|Chain B[auth H]|POM1 Fab Heavy chain|Mus musculus (10090) QVQLQQSGTELVMPGASVKMSCKASGYTFTDYWMHWVKQRPGQGLEWIGSIDPSDSYTSHNEKFKGKATLTVDESSSTAYMQLSSLTSEDSAVYFCSRSGYGYYAMEYWGQGTSVTVSSAKTTPPSVYPLAPGGGATNSMVTLGCLVKGYFPEPVTVTWNSGSLSGGVHTFPAVLQSDLYTLSSSVTVPSSTWPSETVTCNVAHPASSTKVDKKIVPR |
Light Chain: L
Mutation: NULL
| >4DGI_L|Chain C[auth L]|POM1 Fab Light chain|Mus musculus (10090) DIVLTQSPAILSVSPGERVSFSCRASQNIGTSIHWYQQRTNESPRLIIKYASESISGIPSRFSGSGSGTDFTLSINSVESEDIADYYCQQSNTWPYTFGGGTKLELKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSETDQDSKDSTYSMSSTLTLTKDEYERHNTYTCEATHKTSTSPIVKSFNRNE |
Antigen
Chain: A
Mutation: NULL
| >4DGI_A|Chain A|Major prion protein|Homo sapiens (9606) AVVGGLGGYMLGSAMSRPIIHFGSDYEDRYYRENMHRYPNQVYYRPMDEYSNQNNFVHDCVNITIKQHTVTTTTKGENFTETDVKMMERVVEQMCITQYERESQAYYQRGS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: ASP31 TRP33 ASP52 SER54 ASP55 TYR57 TYR101 GLY102 TYR104 L: SER32 TYR50 SER91 ASN92 THR93 TRP94 TYR96 A: ILE138 HIS140 PHE141 GLY142 SER143 ASP144 TYR145 GLU146 ASP147 LYS204 ARG208 GLN212 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
