Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6775 |
| PDBID: | 4BZ2 |
| Chains: | HL_A |
| Organism: | dengue virus type 4, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.03 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | 2D73 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Dengue virus (DENV) type 4 envelope glycoprotein domain III |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >4BZ2_H|Chain B[auth H]|FAB 2D73 HEAVY CHAIN|MUS MUSCULUS (10090) EVQLQQSGPELVKPGASVKISCKASGYTFTDYNMHWVKQSHGKSLEWVGYTYPYNGGIGYNQKFKSKATLTLDNSSRTAYMELRSLTSEDSAVYYCVRRGYRYDGAHFDYWGQGTTLTVSSAKTTAPSVYPLAPVCGGTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSAGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQTITCNVAHPASSTKVDKKIEPR |
Light Chain: L
Mutation: NULL
| >4BZ2_L|Chain C[auth L]|FAB 2D73 LIGHT CHAIN|MUS MUSCULUS (10090) DIKMTQSPSSMYASLGERVTITCKASQGINSDLSWFQQKPGKSPKTLIYRANRLVDGVPSRFSGSGSGQDYSLTISSLEYEDMGIYYCLQYDEFPLTFGAGTKLELKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRN |
Antigen
Chain: A
Mutation: NULL
| >4BZ2_A|Chain A|ENVELOPE PROTEIN|DENGUE VIRUS 4 (11070) VEFKRMCSGKFSIDKEMAETQHGTTVVKVKYEGAGAPCKVPIEIRDVNKEKVVGRIISSTPFAEYTNSVTNIELEPPFGDSYIVIGVGDSALTLHWFRKHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: THR28 THR30 ASP31 ASN33 HIS35 TYR50 TYR52 TYR54 ASN55 GLY57 ARG99 TYR101 ARG102 TYR103 L: ASP32 TYR91 ASP92 GLU93 PHE94 LEU96 A: ILE308 ASP309 LYS310 GLU311 MET312 ALA313 GLU314 THR315 GLN316 LYS323 LYS344 VAL364 TYR377 THR388 LEU389 HIS390 TRP391 PHE392 LYS394 HIS396 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
