Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6774 |
| PDBID: | 4BZ1 |
| Chains: | HL_A |
| Organism: | dengue virus type 4, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.15 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | 3E31 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Dengue virus (DENV) type 4 envelope glycoprotein domain III |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >4BZ1_H|Chain B[auth H]|FAB 3E31 HEAVY CHAIN|MUS MUSCULUS (10090) QVQLQQPGAEFVKPGASVKMSCKASGYTFTSYWINWVKQRPGQGLEWIGDIYPGRGTTNYNENFKSKATLTLDTSSSTAYMQLSSLTSEDSAVYYCSRGSKGAMDYWGQGTSVTVSSAKTTPPSVYPLAPGTAALKSSMVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQTITCNVAHPASSTKVDKKIVPR |
Light Chain: L
Mutation: NULL
| >4BZ1_L|Chain C[auth L]|FAB 3E31 LIGHT CHAIN|MUS MUSCULUS (10090) DIVMSQSPSSLAVSVGEKVTLSCKSSQSLLYSSNQKNHLAWYQQKPGQSPKLLIYWASTRESGVPDRFTGSGSGTDFTLTINSVKAEDLAVYYCQHFYIYPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFAPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRN |
Antigen
Chain: A
Mutation: NULL
| >4BZ1_A|Chain A|ENVELOPE PROTEIN|DENGUE VIRUS 4 (11070) MCSGKFSIDKEMAETQHGTTVVKVKYEGAGAPCKVPIEIRDVNKEKVVGRIISSTPFAEYTNSVTNIELEPPFGDSYIVIGVGDSALTLHWFRKHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: TRP33 ASN35 ASP50 ARG55 THR57 THR58 ASN59 TYR60 GLY99 LYS101 GLY102 L: GLN27 TYR31 SER33 HIS38 PHE97 TYR98 ILE99 TYR100 TYR102 A: ALA313 GLU314 THR315 GLN316 HIS317 GLY318 THR319 VAL321 LYS323 ARG350 ILE352 SER353 SER354 ASN366 GLU368 GLU370 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
