Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6771 |
| PDBID: | 4AM0 |
| Chains: | HL_R |
| Organism: | Homo sapiens, Mus musculus, dengue virus type 4 |
| Method: | XRD |
| Resolution (Å): | 3.02 |
| Reference: | 10.4049/jimmunol.1200227 |
| Antibody | |
| Antibody: | 2H12 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Dengue virus (DENV) type 4 envelope glycoprotein domain III |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >4AM0_H|Chain A, C, E, G[auth H]|FAB 2H12, HEAVY CHAIN|HOMO SAPIENS (9606) DVQLVEPGAELVQPGASVKMSCKASGYTFSSYWINWEKQRPGKGLEWIGNIYPGSGTVNYDDKFKSKATLTIDTSSNTAYMQLSSLTSEDSAVYYCTRGGSHAMDYWGQGTSVTVSSAKTTPPSVYPLAPGSADTTGSSVTLGCLVKGYFPESVTVTWNSGSLSSSVHTFPALLQSGLYTMSSSVTVPSSTWPSQTVTCSVAHPASSTTVDKKLEPR |
Light Chain: L
Mutation: NULL
| >4AM0_L|Chain B, D, F, H[auth L]|FAB 2H12, LIGHT CHAIN|HOMO SAPIENS (9606) DIVMTQSQKFMSTSVGDRVSITCKASQNVRTSVAWYQQKPGQSPKALIYLASNRHTGVPDRFTGSGSGTDFTLTISNVQSEDLADYFCLQHWTYPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRN |
Antigen
Chain: R
Mutation: NULL
| >4AM0_R|Chain I[auth Q], J[auth R], K[auth S], L[auth T]|ENVELOPE PROTEIN,|DENGUE VIRUS (11070) KGMSYTMCSGKFSIDKEMAETQHGTTVVKVKYEGAGAPCKVPIEIRDVNKEKVVGRIISSTPFAEYTNSVTNIELEPPFGDSYIVIGVGDSALTLHWFRKG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: TRP33 ASN35 ASN50 THR57 VAL58 ASN59 LYS65 GLY100 SER101 L: GLN27 HIS91 TRP92 THR93 TYR94 TYR96 R: LYS310 ALA313 GLU314 THR315 GLN316 HIS317 GLY318 VAL321 LYS323 ILE352 SER354 GLU368 GLU370 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
