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Entry information

Complex
AACDB_ID: 6769
PDBID: 4ALA
Chains: HL_C
Organism: dengue virus type 3, Mus musculus
Method: XRD
Resolution (Å): 1.84
Reference: 10.4049/jimmunol.1200227
Antibody
Antibody: 2H12 Fab
Antibody mutation: No
INN (Clinical Trial):
Antigen
Antigen: Dengue virus (DENV) type 3 envelope glycoprotein domain III
Antigen mutation: No
Durg Target: P27915

Sequence information

Antibody

Heavy Chain: H
Mutation: NULL

>4ALA_H|Chain B[auth H]|FAB 2H12 HEAVY CHAIN|MUS MUSCULUS (10090)
DVQLVEPGAELVQPGASVKMSCKASGYTFSSYWINWEKQRPGKGLEWIGNIYPGSGTVNYDDKFKSKATLTIDTSSNTAYMQLSSLTSEDSAVYYCTRGGSHAMDYWGQGTSVTVSSAKTTPPSVYPLAPGCGDTTGSSVTLGCLVKGYFPESVTVTWNSGSLSSSVHTFPALLQSGLYTMSSSVTVPSSTWPSQTVTCSVAHPASSTTVDKKLEPR

Light Chain: L
Mutation: NULL

>4ALA_L|Chain C[auth L]|FAB 2H12 LIGHT CHAIN|MUS MUSCULUS (10090)
DIVMTQSQKFMSTSVGDRVSITCKASQNVRTSVAWYQQKPGQSPKALIYLASNRHTGVPDRFTGSGSGTDFTLTISNVQSEDLADYFCLQHWTYPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRN

Antigen

Chain: C
Mutation: NULL

>4ALA_C|Chain A[auth C]|ENVELOPE PROTEIN|DENGUE VIRUS 3 (11069)
KGMSYAMCLNTFVLKKEVSETQHGTILIKVEYKGEDAPCKIPFSTEDGQGKAHNGRLITANPVVTKKEEPVNIEAEPPFGESNIVIGIGDKALKINWYRKG

Interaction

1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.

Interacting residues (ΔSASA based)

Chain residues position delta_SASA : residuesposition

H: TRP33 ASN35 ASN50 THR57 VAL58 ASN59 LYS65 GLY100 SER101

L: GLN27 ARG30 HIS91 TRP92 THR93 TYR94 TYR96

C: LYS310 SER313 GLU314 THR315 GLN316 HIS317 GLY318 THR319 LEU321 LYS323 LEU351 ILE352 THR353 ALA354 ASN366 GLU368 GLU370

2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.

Interacting residues (Atom distance based)

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