Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6768 |
| PDBID: | 4AL8 |
| Chains: | HL_C |
| Organism: | Dengue virus, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 1.66 |
| Reference: | 10.4049/jimmunol.1200227 |
| Antibody | |
| Antibody: | 2H12 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Dengue virus (DENV) type 1 envelope glycoprotein domain III |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >4AL8_H|Chain B[auth H]|FAB 2H12 HEAVY CHAIN|HOMO SAPIENS (9606) DVQLVEPGAELVQPGASVKMSCKASGYTFSSYWINWEKQRPGKGLEWIGNIYPGSGTVNYDDKFKSKATLTIDTSSNTAYMQLSSLTSEDSAVYYCTRGGSHAMDYWGQGTSVTVSSAKTTPPSVYPLAPGCGDTTGSSVTLGCLVKGYFPESVTVTWNSGSLSSSVHTFPALLQSGLYTMSSSVTVPSSTWPSQTVTCSVAHPASSTTVDKKLEPR |
Light Chain: L
Mutation: NULL
| >4AL8_L|Chain C[auth L]|FAB 2H12 LIGHT CHAIN|HOMO SAPIENS (9606) DIVMTQSQKFMSTSVGDRVSITCKASQNVRTSVAWYQQKPGQSPKALIYLASNRHTGVPDRFTGSGSGTDFTLTISNVQSEDLADYFCLQHWTYPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNE |
Antigen
Chain: C
Mutation: NULL
| >4AL8_C|Chain A[auth C]|ENVELOPE PROTEIN|DENGUE VIRUS (12637) KGMSYVMCTGSFKLEKEVAETQHGTVLVQVKYEGTDAPCKIPFSSQDEKGVTQNGRLITANPIVTDKEKPVNIEAEPPFGESYIVVGAGEKALKLSWFKKG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: TRP33 ASN35 ASN50 THR57 VAL58 ASN59 TYR60 ASP62 LYS65 GLY100 SER101 ALA103 L: GLN27 ARG30 HIS91 TRP92 THR93 TYR94 TYR96 C: LYS310 ALA313 GLU314 THR315 GLN316 HIS317 GLY318 THR319 LEU321 GLN323 ILE352 THR353 ALA354 LYS363 PRO364 ASN366 GLU368 GLU370 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
