Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6756 |
| PDBID: | 3ZTJ |
| Chains: | GH_B |
| Organism: | Influenza A virus (A/Aichi/2/1968(H3N2)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.41 |
| Reference: | 10.1126/science.1205669 |
| Antibody | |
| Antibody: | FI6v3 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H3N2 hemagglutinin HA2 |
| Antigen mutation: | No |
| Durg Target: | P03437 |
Sequence information
Antibody
Heavy Chain: G
Mutation: NULL
| >3ZTJ_G|Chain G, I, K|FI6V3 ANTIBODY HEAVY CHAIN|HOMO SAPIENS (9606) QVQLVESGGGVVQPGRSLRLSCAASGFTFSTYAMHWVRQAPGKGLEWVAVISYDANYKYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCAKDSQLRSLLYFEWLSQGYFDYWGQGTLVTVSSASTKGPSVFPLAPSSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPK |
Light Chain: H
Mutation: NULL
| >3ZTJ_H|Chain H, J, L|FI6V3 ANTIBODY LIGHT CHAIN|HOMO SAPIENS (9606) DIVMTQSPDSLAVSLGERATINCKSSQSVTFNYKNYLAWYQQKPGQPPKLLIYWASTRESGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQHYRTPPTFGQGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: B
Mutation: NULL
| >3ZTJ_B|Chain B, D, F|HEMAGGLUTININ HA2 CHAIN|INFLUENZA A VIRUS (387139) GLFGAIAGFIENGWEGMIDGWYGFRHQNSEGTGQAADLKSTQAAIDQINGKLNRVIEKTNEKFHQIEKEFSEVEGRIQDLEKYVEDTKIDLWSYNAELLVALENQHTIDLTDSEMNKLFEKTRRQLRENAEEMGNGCFKIYHKCDNACIESIRNGTYDHDVYRDEALNNRFQIKG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| G: TYR52 LEU98 ARG99 H: PHE27 TYR32 TYR92 ARG93 B: ILE18 ASP19 GLY20 TRP21 LEU38 LYS39 THR41 GLN42 ALA43 ILE45 ASP46 ILE48 ASN49 LEU52 ASN53 ILE56 GLU57 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
