Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 674 |
| PDBID: | 3UX9 |
| Chains: | D_C |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.80 |
| Reference: | 10.1007/s00109-012-0866-3 |
| Antibody | |
| Antibody: | α1bIgG01 scFv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Interferon alpha-1/13 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: D
Mutation: NULL
| >3UX9_D|Chain B, D|ScFv antibody|Homo sapiens (9606) MADIVLTQPPSVSGAPGQRVTISCSGSSSNIGSNYVSWYQQLPGTAPKLLIYDNNQRPSGVPDRFSGSKSGTSASLAITGLQSEDEADYYCQVRDNNENEWVFGGGTKLTVLGSGGSTITSYNVYYTKLSSSGSEVQLVESGGGLVQPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAISGSGGSTYYADSVKGRFTISRDNSKNTLYLQMNSLRAEDTAVYYCARYIDFGDHMDFWGQGTLVTVSSLEH |
Antigen
Chain: C
Mutation: NULL
| >3UX9_C|Chain A, C|Interferon alpha-1/13|Homo sapiens (9606) SNACDLPETHSLDNRRTLMLLAQMSRISPSSCLMDRHDFGFPQEEFDGNQFQKAPAISVLHELIQQIFNLFTTKDSSAAWDEDLLDKFCTELYQQLNDLEACVMQEERVGETPLMNADSILAVKKYFRRITLYLTEKKYSPCAWEVVRAEIMRSLSLSTNLQERLRRKE |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition D: GLY32 SER33 ASN34 TYR35 ASP53 ASN54 ASN55 GLN56 LYS69 ARG94 ASP95 ASN96 ASN99 GLU100 TRP101 SER165 ALA167 ALA184 ILE185 SER186 GLY187 SER188 SER191 TYR193 TYR233 ASP235 PHE236 GLY237 ASP238 C: SER25 PRO26 SER27 SER28 CYS29 LEU30 MET31 ARG33 HIS34 ASP35 GLN40 GLU142 VAL143 ALA146 GLU147 ARG150 LEU154 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
