Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6736 |
| PDBID: | 3WHE |
| Chains: | 12_H |
| Organism: | Influenza A virus (A/Aichi/2-1/1968(H3N2)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 4.00 |
| Reference: | 10.1128/JVI.00420-14 |
| Antibody | |
| Antibody: | F005-126 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H3N2 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | P03437 |
Sequence information
Antibody
Heavy Chain: 1
Mutation: NULL
| >3WHE_1|Chain M[auth 1], N[auth 3], O[auth 5], P[auth 7], Q[auth 9], R[auth M], S[auth O], T[auth Q], U[auth S], V[auth U], W, X[auth Y]|immunoglobulin heavy chain|Homo sapiens (9606) QVQLVQSGAEVKKPGASVTVSCQVSGYTLTSYGLSWVRQAPGQGLEWVGWINTYDGQTKYVKKFQGRVTMTTHTGTNTAYMEMKSLRSDDTAVYYCARVEGVRGVMGFHYYPMDVWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEP |
Light Chain: 2
Mutation: NULL
| >3WHE_2|Chain AA[auth 0], BA[auth 2], CA[auth 4], DA[auth 6], EA[auth 8], FA[auth N], GA[auth P], HA[auth R], IA[auth T], JA[auth V], Y[auth X], Z|immunoglobulin light chain|Homo sapiens (9606) QSVLTQPPSVSGAPGQRVTISCTGSSSNIGAGYAVHWYQQLPGTAPKLLISGNSNRPSGVPDRFSGSKSGTSASLAITGLQAEDEADYYCQSYDSSLSGSVFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECSARQ |
Antigen
Chain: H
Mutation: NULL
| >3WHE_H|Chain A, B, C, D, E, F, G, H, I, J, K, L|Hemagglutinin|Influenza A virus (1391655) STATLCLGHHAVPNGTLVKTITDDQIEVTNATELVQSSSTGKICNNPHRILDGIDCTLIDALLGDPHCDVFQNETWDLFVERSKAFSNCYPYDVPDYASLRSLVASSGTLEFITEGFTWTGVTQNGGSNACKRGPGSGFFSRLNWVTKSGSTYPVLNVTMPNNDNFDKLYIWGVHHPSTNQEQTSLYVQASGRVTVSTRRSQQTIIPNIGSRPWVRGLSSRISIYWTIVKPGDVLVINSNGNLIAPRGYFKMRTGKSSIMRSDAPIDTCISECITPNGSIPNDKPFQNVNKITYGACPKYVKQNTLKLATGMRNVPEKQTRGLFGAIAGFIENGWEGMIDGWYGFRHQNSEGTGQAADLKSTQAAIDQINGKLNRVIEKTNEKFHQIEKEFSEVEGRIQDLEKYVEDTKIDLWSYNAELLVALENQHTIDLTDSEMNKLFEKTRRQLRENAEDMGNGCFKIYHKCDNACIESIRNGTYDHDVYRDEALNNRFQ |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| 1: TYR27 SER31 TYR32 TYR54 GLU100 VAL102 ARG103 GLY104 VAL105 TYR110 2: ALA31 TYR33 H: GLY41 LYS42 SER83 LYS84 ALA85 PHE86 ARG261 SER262 ASP263 ALA264 PRO265 PRO276 ASN277 GLU390 PHE391 SER392 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
