Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6703 |
| PDBID: | 3UBX |
| Chains: | GI_D |
| Organism: | Mus musculus |
| Method: | XRD |
| Resolution (Å): | 3.10 |
| Reference: | 10.1074/jbc.M111.308783 |
| Antibody | |
| Antibody: | L363 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Antigen-presenting glycoprotein CD1d1 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: G
Mutation: NULL
| >3UBX_G|Chain F[auth G], H|L363 heavy chain (IGHV9-4*02)|Mus musculus (10090) QIQLVQSGPELKKPGETVRISCKASGYSFTNYGMHWVKQAPGKGLKWVGWINTYTGEPTYADDFKGRFAFSLETSASTAYLEINNLKNEDMATYLCASAAGIRWAWFAWWGQGTLVTVSAAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPRGP |
Light Chain: I
Mutation: NULL
| >3UBX_I|Chain E[auth I], G[auth L]|L363 light chain (IGKV13-84*01)|Mus musculus (10090) DIQMTQSSSSFSVSLGDRATITCKASEDIYNRIAWYQQKPGNVPRLLISGATSLETGVPSRFSGSGSGKDYTLSITSLQTEDVATYYCQHYWSSPLTFGAGTKLELKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: D
Mutation: NULL
| >3UBX_D|Chain A, C[auth D]|Antigen-presenting glycoprotein CD1d1|Mus musculus (10090) SEAQQKNYTFRCLQMSSFANRSWSRTDSVVWLGDLQTHRWSNDSATISFTKPWSQGKLSNQQWEKLQHMFQVYRVSFTRDIQELVKMMSPKEDYPIEIQLSAGCEMYPGNASESFLHVAFQGKYVVRFWGTSWQTVPGAPSWLDLPIKVLNADQGTSATVQMLLNDTCPLFVRGLLEAGKSDLEKQEKPVAWLSSVPSSAHGHRQLVCHVSGFYPKPVWVMWMRGDQEQQGTHRGDFLPNADETWYLQATLDVEAGEEAGLACRVKHSSLGGQDIILYWHHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| I: TYR30 ASN31 ARG32 GLY50 THR52 SER53 SER67 GLY68 TRP92 G: THR30 ASN31 TYR32 ASN52 TYR54 THR55 GLU57 ALA100 GLY101 ILE102 ARG103 TRP104 TRP106 D: HIS68 GLN71 VAL72 VAL75 SER76 ARG79 ASP80 GLU83 LEU84 LYS86 MET87 LYS91 LEU145 LYS148 VAL149 LEU150 ALA152 ASP153 GLN154 GLY155 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
