Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 67 |
| PDBID: | 1JHL |
| Chains: | HL_A |
| Organism: | Mus musculus, Phasianus colchicus |
| Method: | XRD |
| Resolution (Å): | 2.40 |
| Reference: | 10.1073/pnas.90.16.7711 |
| Antibody | |
| Antibody: | D11.15 Fv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | PHEASANT EGG WHITE Lysozyme |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >1JHL_H|Chain B[auth H]|IGG1-KAPPA D11.15 FV (HEAVY CHAIN)|Mus musculus (10090) QVQLQQSGAELVRPGASVKLSCKASGYTFISYWINWVKQRPGQGLEWIGNIYPSDSYTNYNQKFKDKATLTVDKSSSTAYMQLSSPTSEDSAVYYCTRDDNYGAMDYWGQGTTVTV |
Light Chain: L
Mutation: NULL
| >1JHL_L|Chain A[auth L]|IGG1-KAPPA D11.15 FV (LIGHT CHAIN)|Mus musculus (10090) DIELTQSPSYLVASPGETITINCRASKSISKSLAWYQEKPGKTNNLLIYSGSTLQSGIPSRFSGSGSGTDFTLTISSLEPEDFAMYICQQHNEYPWTFGGGTKLEIKR |
Antigen
Chain: A
Mutation: NULL
| >1JHL_A|Chain C[auth A]|PHEASANT EGG WHITE LYSOZYME|Phasianus colchicus (9054) KVYGRCELAAAMKRMGLDNYRGYSLGNWVCAAKFESNFNTGATNRNTDGSTDYGILQINSRWWCNDGRTPGSKNLCHIPCSALLSSDITASVNCAKKIVSDGDGMNAWVAWRKHCKGTDVNVWIRGCRL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: SER28 SER30 TYR49 ASN92 GLU93 TYR94 TRP96 H: SER31 TYR32 TRP33 TYR52 SER54 ASP55 TYR57 ASN59 ASP99 ASN101 TYR102 GLY103 A: ARG21 GLY22 TYR23 GLY102 ASP103 GLY104 ASN106 TRP111 ARG112 LYS113 LYS116 GLY117 THR118 ASP119 VAL120 ASN121 ARG125 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
