Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 669 |
| PDBID: | 3UC0 |
| Chains: | IM_B |
| Organism: | dengue virus type 4, Pan troglodytes |
| Method: | XRD |
| Resolution (Å): | 2.71 |
| Reference: | 10.1038/emboj.2011.439 |
| Antibody | |
| Antibody: | 5H2 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | dengue virus type 4 envelope protein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: I
Mutation: NULL
| >3UC0_I|Chain C[auth H], D[auth I]|Heavy chain, monoclonal antibody 5H2|Pan troglodytes (9598) EVQLLESGPGLVKPSETLSLTCTVSGGSISDFYWSWLRQSPGKGLEWIGYAHSRVSAYYNPSLKSRVTISVDTSKNQISLRLSAVTAADTALYYCARQGTGTTGVSEDSFDLWGQGTKVIVSLASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVDHKPSNTKVDKKVEPKSCDTTSHHHHHH |
Light Chain: M
Mutation: NULL
| >3UC0_M|Chain E[auth L], F[auth M]|Light chain, monoclonal antibody 5H2|Pan troglodytes (9598) AELQMTQSPSSLSASVGDRVTITCRASQDISIRLNWYQQKPGKAPKLLIYDASTLESGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQFNSYPLTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVACLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDNTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: B
Mutation: NULL
| >3UC0_B|Chain A, B|envelope protein|Dengue virus 4 (11070) MRCVGVGNRDFVEGVSGGAWVDLVLEHGGCVTTMAQGKPTLDFELTKTTAGGLEYTVVVTVHNGDTHAVGNDTSNHGVTAMITPRSPSVEVKLPDYGELTLDCEPRSGTGHLKCKVRMEKLRIKGMSPFEDDDDKAGWSHPQFEKGGGSGGGSGGGSWSHPQFEK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition I: SER30 ASP31 TYR33 TYR50 HIS52 ARG54 VAL55 SER56 TYR58 GLN98 GLY99 THR100 GLY101 THR102 THR103 GLU107 ASP108 M: ARG33 PHE92 ASN93 SER94 TYR95 B: THR155 GLY159 VAL160 THR161 ALA162 MET163 THR165 SER168 SER170 VAL171 GLU172 VAL173 LYS174 PRO176 ASP177 GLY179 GLU180 LYS291 ARG293 LYS295 GLY296 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
