Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6687 |
| PDBID: | 3SO3 |
| Chains: | CB_A |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.10 |
| Reference: | 10.1016/j.jmb.2011.11.036 |
| Antibody | |
| Antibody: | A11 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Membrane-type serine protease 1 (MT-SP1) |
| Antigen mutation: | Yes |
| Durg Target: | Q9Y5Y6 |
Sequence information
Antibody
Heavy Chain: C
Mutation: NULL
| >3SO3_C|Chain C|A11 FAB heavy chain|Homo sapiens (9606) EVQLVQSGGGLVKPGGSLRLSCAASGFTFSSYAMSWVRQAPGKGLEWVSAISGSGGSTYYADSVKGRFTISRDNSKNTLYLQMSSLRAEDTAVYYCVKDLGIAARRFVSGAFDIWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDTKVEPKSC |
Light Chain: B
Mutation: NULL
| >3SO3_B|Chain B|A11 FAB light chain|Homo sapiens (9606) EIVLTQSPGTLSLSPGERATLSCRASQSVSSSYLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTDFTLTINSLEPEDFAVYYCQQRSNWPPGYTFGQGTKVEITRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: C117S
| >3SO3_A|Chain A|Suppressor of tumorigenicity 14 protein|Homo sapiens (9606) VVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIALLELEKPAEYSSMVRPISLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQTTCENLLPQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCAQRNKPGVYTRLPLFRDWIKENTGV |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: ILE2 SER27 VAL28 SER29 SER30 SER31 TYR32 GLN90 ARG91 SER92 ASN93 TRP94 GLY95 TYR96 C: THR28 SER30 SER31 ALA33 ALA50 GLY52 SER53 GLY55 SER56 TYR58 ALA99 A: HIS57 PHE94 ASN95 ASP96 PHE97 THR98 PHE99 ASP100 TYR146 ASN170 LEU171 LEU172 PRO173 GLN174 GLN175 ILE176 THR177 PRO178 ARG179 ASP189 SER190 CYS191 GLN192 SER195 VAL213 TRP215 GLY216 ASP217 GLY219 CYS220 LYS224 GLY226 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
