Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6684 |
| PDBID: | 3S88 |
| Chains: | HL_I |
| Organism: | Mus musculus, Sudan ebolavirus |
| Method: | XRD |
| Resolution (Å): | 3.35 |
| Reference: | 10.1038/nsmb.2150 |
| Antibody | |
| Antibody: | 16F6 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Sudan Ebolavirus envelope glycoprotein (strain Gulu) |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >3S88_H|Chain A[auth H]|16F6 - Heavy chain|Mus musculus (10090) EVQLVESGGGLVTPGGSLKLSCAASGFAFNYYDMFWVRQNTEKRLEWVAYINSGGGNTYYPDTVKGRFTISRDNAKKTLFLQMSSLRSEDTAMYYCARQLYGNSFFDYWGQGTSLTVSAAKTTPPSVYPLAPGSAAAAASMVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSPRPSETVTCNVAHPASSTKVDKKIVPAD |
Light Chain: L
Mutation: NULL
| >3S88_L|Chain D[auth L]|16F6 - Light chain|Mus musculus (10090) DIVMTQSHKFMSTSVGDRVTITCKASQDVTTAVAWYQQKPGHSPKLLIYWASTRHTGVPDRFTGSGSGTAFTLTLNSVQAEDLALYYCQQHYSTPLTFGAGTKLELKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRN |
Antigen
Chain: I
Mutation: NULL
| >3S88_I|Chain B[auth I]|Envelope glycoprotein|Sudan ebolavirus (186540) YPYDVPDYAIEGRGARSMPLGVVTNSTLEVTEIDQLVCKDHLASTDQLKSVGLNLEGSGVSTDIPSATKRWGFRSGVPPKVVSYEAGEWAENCYNLEIKKPDGSECLPPPPDGVRGFPRCRYVHKAQGTGPCPGDYAFHKDGAFFLYDRLASTVIYRGVNFAEGVIAFLILAKPKETFLQSPPIREAVNYTENTSSYYATSYLEYEIENFGAQHSTTLFKIDNNTFVRLDRPHTPQFLFQLNDTIHLHQQLSNTTGRLIWTLDANINADIGEWAFWENKKNLSEQLRGEELSFEALSL |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: GLU1 VAL2 PHE27 ALA28 ASN30 TYR31 TYR32 LYS77 ARG98 LEU100 TYR101 TYR108 L: TYR49 HIS55 THR56 I: SER32 PRO34 ASN40 THR42 LEU43 GLU44 VAL45 THR46 GLU47 GLN50 VAL52 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
