Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6661 |
| PDBID: | 3QWO |
| Chains: | AB_C |
| Organism: | Mus musculus, Staphylococcus aureus |
| Method: | XRD |
| Resolution (Å): | 1.90 |
| Reference: | 10.1016/j.jmb.2011.04.044 |
| Antibody | |
| Antibody: | Motavizumab Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | Motavizumab(Phase-III) |
| Antigen | |
| Antigen: | motavizumab epitope in Respiratory syncytial virus (RSV) fusion glycoprotein |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >3QWO_A|Chain B[auth A], D[auth H]|motavizumab heavy chain|Mus musculus (10090) QVTLRESGPALVKPTQTLTLTCTFSGFSLSTAGMSVGWIRQPPGKALEWLADIWWDDKKHYNPSLKDRLTISKDTSKNQVVLKVTNMDPADTATYYCARDMIFNFYFDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDK |
Light Chain: B
Mutation: NULL
| >3QWO_B|Chain A[auth B], C[auth L]|motavizumab light chain|Mus musculus (10090) DIQMTQSPSTLSASVGDRVTITCSASSRVGYMHWYQQKPGKAPKLLIYDTSKLASGVPSRFSGSGSGTEFTLTISSLQPDDFATYYCFQGSGYPFTFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: C
Mutation: NULL
| >3QWO_C|Chain E[auth C], F[auth P]|motavizumab epitope scaffold|Staphylococcus aureus (1280) SYNDEKKLASNEIANLPNLNEEQRSAFLSSINDDPSQSANLLAEAKKLNDAQADEVD |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: ILE2 ARG29 VAL30 GLY31 TYR32 ASP50 GLY91 SER92 GLY93 TYR94 A: SER30 THR31 ALA32 GLY33 TRP52 TRP53 ASP54 LYS56 HIS58 ILE97 PHE98 ASN99 C: SER4 TYR5 ASN6 ASP7 LYS9 LYS10 LEU11 SER13 ASN14 ALA17 GLU24 ARG27 SER28 LEU31 SER32 ASN35 ASP36 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
