Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6636 |
| PDBID: | 3J6U |
| Chains: | HL_C |
| Organism: | dengue virus type 3, Homo sapiens |
| Method: | EM |
| Resolution (Å): | 9.00 |
| Reference: | 10.1038/ncomms7341 |
| Antibody | |
| Antibody: | 5J7 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Dengue virus (DENV) type 3 envelope protein |
| Antigen mutation: | No |
| Durg Target: | P27915 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >3J6U_H|Chain G[auth H]|Fab 5J7 heavy chain|Homo sapiens (9606) WVPGSWAQVQLVQSGAELRKPGSSVKVSCRASGGTFSSYTFNWVRQAPGQGLEWMGGFIPVFNTTNYAQTFQGRVTIAADKSTSTAYMELRSLRSEDTAIYYCARDKELLFSRAFDIWGQGTMVTVSSAGTKGPS |
Light Chain: L
Mutation: NULL
| >3J6U_L|Chain H[auth L]|Fab 5J7 light chain|Homo sapiens (9606) WVPGVHSDIQMTQSPSSLSASVGDRVTITCRASQSISRYLNWYQREPGKAPKLLIYGASSLQRGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQQSQYIPYTFGQGTKVDIKRTVA |
Antigen
Chain: C
Mutation: NULL
| >3J6U_C|Chain A, C, E|envelope protein|Dengue virus 3 (11069) MRCVGVGNRDFVEGLSGATWVDVVLEHGGCVTTMAKNKPTLDIELQKTEATQLATLRKLCIEGKITNITTDSRCPTQGEAVLPEEQDQNYVCKHTYVDRGWGNGCGLFGKGSLVTCAKFQCLEPIEGKVVQYENLKYTVIITVHTGDQHQVGNETQGVTAEITPQASTTEAILPEYGTLGLECSPRTGLDFNEMILLTMKNKAWMVHRQWFFDLPLPWASGATTETPTWNRKELLVTFKNAHAKKQEVVVLGSQEGAMHTALTGATEIQNSGGTSIFAGHLKCRLKMDKLELKGMSYAMCTNTFVLKKEVSETQHGTILIKVEYKGEDAPCKIPFSTEDGQGKAHNGRLITANPVVTKKEEPVNIEAEPPFGESNIVIGIGDNALKINWYKKGSSIGKMFEATARGARRMAILGDTAWDFGSVGGVLNSLGKMVHQIFGSAYTALFSGVSWVMKIGIGVLLTWIGLNSKNTSMSFSCIAIGIITLYLGAVVQA |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: SER38 TYR39 LYS107 GLU108 LEU109 LEU110 L: ASP8 TYR100 ILE101 PRO102 C: ALA50 THR51 GLN52 LEU53 THR223 THR224 GLU225 GLY273 THR274 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
