Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6630 |
| PDBID: | 3J42 |
| Chains: | IJ_D |
| Organism: | dengue virus type 2, Mus musculus |
| Method: | EM |
| Resolution (Å): | 21.00 |
| Reference: | 10.1128/JVI.00472-13 |
| Antibody | |
| Antibody: | 2H2 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Dengue virus type 2 envelope protein E |
| Antigen mutation: | No |
| Durg Target: | P12823 |
Sequence information
Antibody
Heavy Chain: I
Mutation: NULL
| >3J42_I|Chain G, I, K|Ig heavy chain V region MOPC 21, Igh protein chimera|Mus musculus (10090) DVQLVESGGGLVQPGGSRKLSCAASGFTFSSFGMHWVRQAPEKGLEWVAYISSGSSTLHYADTVKGRFTISRDNPKNTLFLQMTSLRSEDTAMYYCARWGNYPHYAMDYWGQGTSVTVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSGLYTLSSSVTVTSSTWPSQTITCNVAHPASSTKVDKKIEPRV |
Light Chain: J
Mutation: NULL
| >3J42_J|Chain H, J, L|Ig kappa chain V-V region MOPC 21, Anti-colorectal carcinoma light chain chimera|Mus musculus (10090) NIVMTQSPKSMSMSVGERVTLTCKASENVGTYVSWYQQKPEQSPKLLIYGASNRYTGVPDRFTGSGSATDFTLTISSVQAEDLADYHCGQSYSTPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRN |
Antigen
Chain: D
Mutation: NULL
| >3J42_D|Chain D, E, F|PrM|Dengue virus 2 (11060) FHLTTRNGEPHMIVSRQEKGKSLLFKTEDGVNMCTLMAMDLGELCEDTITYKCPLLRQNEPEDIDCWCNSTSTWVTYGTCT |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| I: TYR102 PRO103 D: PHE1 HIS2 LEU3 THR4 PHE25 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
