Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6628 |
| PDBID: | 3J3P |
| Chains: | HL_1 |
| Organism: | Mus musculus, Human poliovirus 1 Mahoney |
| Method: | EM |
| Resolution (Å): | 9.10 |
| Reference: | 10.4049/jimmunol.1202014 |
| Antibody | |
| Antibody: | C3 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Human poliovirus 1 capsid protein VP1 |
| Antigen mutation: | No |
| Durg Target: | P03300 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >3J3P_H|Chain B[auth H]|C3 antibody, heavy chain|Mus musculus (10090) QVQLQQSGAELVRPGTSVKVSCKASGYAFTNYLIQWIKQRPGQGLEWIGVINPGSGGTDYNANFKGKATLTADKSSSIVYMQLSSLTSDDSAVYFCARDFYDYDVGFDYWGQGTTLTVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIEPR |
Light Chain: L
Mutation: NULL
| >3J3P_L|Chain A[auth L]|C3 antibody, light chain|Mus musculus (10090) DVVMTQTPLSLPVSLGDQASISCSSSQSLVHSNGKTYLHWYLQKPGQSPKLLIYKVSNRFSGVPDRFSGSGSGTYFTLKISRVEAEDLGVYFCSQSTHVPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSEVQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: 1
Mutation: NULL
| >3J3P_1|Chain C[auth 1]|Protein VP1|Human poliovirus 1 (12081) GLGQMLESMIDNTVRETVGAATSRDALPNTEASGPTHSKEIPALTAVETGATNPLVPSDTVQTRHVVQHRSRSESSIESFFARGACVTIMTVDNPASTTNKDKLFAVWKITYKDTVQLRRKLEFFTYSRFDMELTFVVTANFTETNNGHALNQVYQIMYVPPGAPVPEKWDDYTWQTSSNPSIFYTYGTAPARISVPYVGISNAYSHFYDGFSKVPLKDQSAALGDSLYGAASLNDFGILAVRVVNDHNPTKVTSKIRVYLKPKHIRVWCPRPPRAVAYYGPGVDYKDGTLTPLSTKDLTTY |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: SER27 ASN28 H: GLY56 THR57 TYR97 ASP98 TYR99 1: THR91 SER97 THR98 ASN100 LYS101 ASP102 LEU104 PHE105 ALA106 VAL107 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
