Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6618 |
| PDBID: | 3GBN |
| Chains: | HL_B |
| Organism: | Influenza A virus (A/Brevig Mission/1/1918(H1N1)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.20 |
| Reference: | 10.1126/science.1171491 |
| Antibody | |
| Antibody: | CR6261 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | Diridavumab(Phase-II) |
| Antigen | |
| Antigen: | Influenza A virus H1N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >3GBN_H|Chain C[auth H]|Fab Heavy Chain|Homo sapiens (9606) EVQLVESGAEVKKPGSSVKVSCKASGGPFRSYAISWVRQAPGQGPEWMGGIIPIFGTTKYAPKFQGRVTITADDFAGTVYMELSSLRSEDTAMYYCAKHMGYQVRETMDVWGKGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK |
Light Chain: L
Mutation: NULL
| >3GBN_L|Chain D[auth L]|Fab Lambda Light Chain|Homo sapiens (9606) QSVLTQPPSVSAAPGQKVTISCSGSSSNIGNDYVSWYQQLPGTAPKLLIYDNNKRPSGIPDRFSGSKSGTSATLGITGLQTGDEANYYCATWDRRPTAYVVFGGGTKLTVLGAAAGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: B
Mutation: NULL
| >3GBN_B|Chain B|Hemagglutinin|Influenza A virus (A/Brevig Mission/1/1918(H1N1)) (88776) GLFGAIAGFIEGGWTGMIDGWYGYHHQNEQGSGYAADQKSTQNAIDGITNKVNSVIEKMNTQFTAVGKEFNNLERRIENLNKKVDDGFLDIWTYNAELLVLLENERTLDFHDSNVRNLYEKVKSQLKNNAKEIGNGCFEFYHKCDDACMESVRNGTYDYPKYSEESKLNREEIDGVSGR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: GLY27 PRO28 PHE29 ARG30 SER31 PRO52 ILE53 PHE54 THR56 PHE74 GLY97 TYR98 GLN99 B: ILE18 ASP19 GLY20 TRP21 ALA36 GLN38 THR41 GLN42 ILE45 ASP46 ILE48 THR49 VAL52 ASN53 ILE56 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
