Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6609 |
| PDBID: | 3FKU |
| Chains: | S_I |
| Organism: | Influenza A virus (A/Viet Nam/1203/2004(H5N1)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.20 |
| Reference: | 10.1038/nsmb.1566 |
| Antibody | |
| Antibody: | F10 scFv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H5N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: S
Mutation: NULL
| >3FKU_S|Chain M[auth S], N[auth T], O[auth U], P[auth X], Q[auth Y], R[auth Z]|Neutralizing antibody F10|Homo sapiens (9606) QVQLVQSGAEVKKPGSSVKVSCTSSEVTFSSFAISWVRQAPGQGLEWLGGISPMFGTPNYAQKFQGRVTITADQSTRTAYMDLRSLRSEDTAVYYCARSPSYICSGGTCVFDHWGQGTLVTVSSGGGGSGGGGSGGGGIQPGLTQPPSVSKGLRQTATLTCTGNSNNVGNQGAAWLQQHQGHPPKLLSYRNNDRPSGISERFSASRSGNTASLTITGLQPEDEADYYCSTWDSSLSAVVFGGGTKLTVLGQPKAAPSAAAEQKLISEEDLNGAAHHHHHH |
Antigen
Chain: I
Mutation: NULL
| >3FKU_I|Chain A, C, E, G, I, K|Hemagglutinin|Influenza A virus (284218) ADPGYLLEDQICIGYHANNSTEQVDTIMEKNVTVTHAQDILEKKHNGKLCDLDGVKPLILRDCSVAGWLLGNPMCDEFINVPEWSYIVEKANPVNDLCYPGDFNDYEELKHLLSRINHFEKIQIIPKSSWSSHEASLGVSSACPYQGKSSFFRNVVWLIKKNSTYPTIKRSYNNTNQEDLLVLWGIHHPNDAAEQTKLYQNPTTYISVGTSTLNQRLVPRIATRSKVNGQSGRMEFFWTILKPNDAINFESNGNFIAPEYAYKIVKKGDSTIMKSELEYGNCNTKCQTPMGAINSSMPFHNIHPLTIGECPKYVKSNRLVLATGLRNSPQRERRRKKR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| S: SER25 VAL27 SER30 MET54 PHE55 GLN74 SER75 ARG77 I: HIS12 HIS32 ALA33 GLN34 ILE36 SER292 MET293 PRO294 THR319 GLY320 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
