Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6604 |
| PDBID: | 3FKU |
| Chains: | T_L |
| Organism: | Influenza A virus (A/Viet Nam/1203/2004(H5N1)), Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.20 |
| Reference: | 10.1038/nsmb.1566 |
| Antibody | |
| Antibody: | F10 scFv |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus H5N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: T
Mutation: NULL
| >3FKU_T|Chain M[auth S], N[auth T], O[auth U], P[auth X], Q[auth Y], R[auth Z]|Neutralizing antibody F10|Homo sapiens (9606) QVQLVQSGAEVKKPGSSVKVSCTSSEVTFSSFAISWVRQAPGQGLEWLGGISPMFGTPNYAQKFQGRVTITADQSTRTAYMDLRSLRSEDTAVYYCARSPSYICSGGTCVFDHWGQGTLVTVSSGGGGSGGGGSGGGGIQPGLTQPPSVSKGLRQTATLTCTGNSNNVGNQGAAWLQQHQGHPPKLLSYRNNDRPSGISERFSASRSGNTASLTITGLQPEDEADYYCSTWDSSLSAVVFGGGTKLTVLGQPKAAPSAAAEQKLISEEDLNGAAHHHHHH |
Antigen
Chain: L
Mutation: NULL
| >3FKU_L|Chain B, D, F, H, J, L|Hemagglutinin|Influenza A virus (284218) GLFGAIAGFIEGGWQGMVDGWYGYHHSNEQGSGYAADKESTQKAIDGVTNKVNSIIDKMNTQFEAVGREFNNLERRIENLNKKMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYDKVRLQLRDNAKELGNGCFEFYHKCDNECMESVRNGTYDYPQYSEEARLKREEISGVRSLVPR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| T: GLU26 VAL27 THR28 SER31 PHE32 MET54 PHE55 THR57 PRO100 SER101 TYR102 ILE103 SER105 THR108 ARG190 L: VAL18 ASP19 GLY20 TRP21 LYS38 GLU39 THR41 GLN42 ILE45 ASP46 THR49 VAL52 ASN53 ILE56 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
