Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6577 |
| PDBID: | 2BDN |
| Chains: | HL_A |
| Organism: | Homo sapiens, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.53 |
| Reference: | 10.1093/protein/gzl015 |
| Antibody | |
| Antibody: | 11K2 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Monocyte chemoattractant protein -1 (MCP-1) |
| Antigen mutation: | No |
| Durg Target: | P13500 |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >2BDN_H|Chain C[auth H]|Antibody heavy chain 11K2|Mus musculus (10090) EVQLQQSGAELVKAGASVKLSCPASGLNIKDTYMHWVKQRPEQGLEWIGRIDPANGNTKFDPKFQGKATITADTSSNTAYLQLSSLTSEDTAVYYCARGVFGFFDYWGQGTTLTVSSAKTTAPSVYPLAPVCGDTTGSSVTLGCLVKGYFPEPVTLTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVTSSTWPSQSITCNVAHPASSTKVDKKIVPR |
Light Chain: L
Mutation: NULL
| >2BDN_L|Chain B[auth L]|Antibody light chain 11K2|Mus musculus (10090) DIQMTQSSSSFSVSLGDRVTITCKATEDIYNRLAWYQQKPGSAPRLLISGATSLETGVPSRFSGSGSGKDYTLSITSLQTEDVATYYCQQFWSAPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNRNEC |
Antigen
Chain: A
Mutation: NULL
| >2BDN_A|Chain A|Small inducible cytokine A2|null QPDAINAPVTCCYNFTNRKISVQRLASYRRITSSKCPKEAVIFKTIVAKEICADPKQKWVQDSMDHLDKQTQTPKT |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: TYR30 ARG32 SER49 GLY50 SER53 GLU55 THR56 PHE91 TRP92 H: GLU1 VAL2 GLY26 ASN28 LYS30 ASP31 THR32 TYR33 ASP52 ALA54 ARG98 GLY99 VAL100 PHE101 PHE103 ASP105 TYR106 A: TYR28 ARG30 THR32 SER33 SER34 LYS35 PRO37 LYS38 GLU39 ALA40 VAL41 PRO55 LYS56 GLN61 MET64 ASP65 ASP68 LYS69 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
