Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 657 |
| PDBID: | 3TJE |
| Chains: | HL_F |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 1.93 |
| Reference: | 10.1038/cdd.2011.208 |
| Antibody | |
| Antibody: | E09 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Tumor necrosis factor receptor superfamily member 6 (CD95/FAS) |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >3TJE_H|Chain B[auth H]|Fab E09, heavy chain|Homo sapiens (9606) QLQLQESGPGLVKPSETLSLTCTVSGASISANSYYGVWVRQSPGKGLEWVGSIAYRGNSNSGSTYYNPSLKSRATVSVDTSKNQVSLRLTSVTAADTALYYCARRQLLDDGTGYQWAAFDVWGQGTMVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHTCPPCP |
Light Chain: L
Mutation: NULL
| >3TJE_L|Chain A[auth L]|Fab E09, light chain|Homo sapiens (9606) QSVLTQPPSVSEAPRQTVTISCSGNSFNIGRYPVNWYQQLPGKAPKLLIYYNNLRFSGVSDRFSGSKSGTSASLAIRDLLSEDEADYYCSTWDDTLKGWVFGGGTKVTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: F
Mutation: NULL
| >3TJE_F|Chain C[auth F]|Tumor necrosis factor receptor superfamily member 6|Homo sapiens (9606) RLSSKSVNAQVTDINSKGLELRKTVTTVETQNLEGLHHDGQFCHKPCPPGERKARDCTVNGDEPDCVPCQEGKEYTDKAHFSSKCRRCRLCDEGHGLEVEINCTRTQNTKCRCKPNFFCNSTVCEHCDPCTKCEHGIIKECTLTSNTKCKEEGSRS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| L: ARG31 TYR32 PRO33 TYR51 ASN52 TRP92 ASP94 LYS97 TRP99 H: SER33 TYR34 TYR35 ALA54 TYR55 ARG56 SER59 SER61 GLY62 SER63 THR64 TYR65 ARG105 GLN106 LEU107 THR112 GLY113 TYR114 GLN115 TRP116 ALA117 F: ASP39 GLY40 GLN41 PHE42 CYS43 HIS44 LYS45 PRO46 PRO48 PRO49 THR58 VAL59 ASN60 GLY61 TYR75 ASP77 LYS78 ALA79 HIS80 PHE81 ARG86 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
