| Complex | |
| AACDB_ID: | 6569 |
| PDBID: | 5VK2 |
| Chains: | HL_A |
| Organism: | Lassa virus Josiah, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 3.20 |
| Reference: | 10.1126/science.aam7260 |
| Antibody | |
| Antibody: | 37.7H Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | The arenavirus Lassa GPC glycoprotein |
| Antigen mutation: | Yes |
| Durg Target: | |
Antibody
Heavy Chain: H
Mutation: NULL
| > |
Light Chain: L
Mutation: NULL
| > |
Antigen
Chain: A
Mutation: R207C/L258R/L259R
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
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2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
Within the threshold, the structure has no interacting amino acids and cannot be displayed. This may be due to the following reasons: