Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6535 |
| PDBID: | 7SA6 |
| Chains: | HL_A |
| Organism: | Neisseria meningitidis serogroup B, Mus musculus |
| Method: | XRD |
| Resolution (Å): | 2.90 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | JAR5 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Factor H-binding protein 2416 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >7SA6_H|Chain B[auth H]|JAR5 Heavy Chain|Mus musculus (10090) MEFGLSWVFLVAILEGVHCQVQMQQPGAELVKPGASVKLSCKASGYTFISYWMHWVKQRPGRGLEWIGRIAPDTGIIYYNEKFKNKATLTVDTPSSTAYMQLNSLTSEDSAVYYCARYLKYDGSTYRFDYWGQGTTLTVSSAKTTPPSVYPLAPGCGDTTGSSVTLGCLVKGYFPEPVTVTWNSGSLSSGVHTFPAVLQSDLYTLSSSVTVPSSPWPSETVTCNVAHPASSTKVDKKLVPRDCGGSENLYFQ |
Light Chain: L
Mutation: NULL
| >7SA6_L|Chain C[auth L]|JAR5 Light Chain|Mus musculus (10090) DIVMTQAAPSVPVTPGESVSISCRSSKSLLHSNGNTYLFWFLQRPGQSPQLLIYRMSNLASGVPDRFSGSGSGTSFTLRISRVEAEDVGVYYCMQHLEYPYTFGGGTKLEIKRADAAPTVSIFPPSSEQLTSGGASVVCFLNNFYPKDINVKWKIDGSERQNGVLNSWTDQDSKDSTYSMSSTLTLTKDEYERHNSYTCEATHKTSTSPIVKSFNR |
Antigen
Chain: A
Mutation: NULL
| >7SA6_A|Chain A|Factor H-binding protein 2416|Neisseria meningitidis serogroup B (491) MGPDSDRLQQRRVAADIGTGLADALTAPLDHKDKGLKSLTLEDSIRQNGTLTLSAQGAEKTFKAGDKDNSLNTGKLKNDKISRFDFVQKIEVDGQTITLASGEFQIYKQNHSAVVALQIEKIQDSEHSGKLVNKRQFRISGLGGEHTAFNQLPGGKAEYHGKAFSSDDPNGRLHYSIDFTKKQGYGRIEHLKTLEQNVELAAAELKADEKSHAVILGDTRYNGAEKGSYHLALFGDRAQEIAGSAEVKTVNSIHHIGIAGKQLEHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: TYR27 THR28 SER31 TYR32 TRP33 ARG50 ASP54 THR55 ILE57 TYR59 ARG98 TYR99 LEU100 LYS101 TYR102 ASP103 GLY104 SER105 THR106 TYR107 ARG108 L: HIS31 SER32 ASN33 ASN35 TYR37 HIS96 LEU97 TYR99 TYR101 A: ILE85 VAL87 ASP88 GLY89 GLN90 THR91 ILE92 THR93 LEU94 LYS116 GLN118 SER120 GLU121 HIS122 SER123 GLY124 LYS125 LEU126 VAL127 ASN128 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
