Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6534 |
| PDBID: | 7S8H |
| Chains: | BC_A |
| Organism: | Lassa virus Josiah, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.70 |
| Reference: | 10.1016/j.celrep.2022.110841 |
| Antibody | |
| Antibody: | 36.1F Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Lassa virus glycoprotein G2 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: B
Mutation: NULL
| >7S8H_B|Chain D[auth B]|36.1F Fab Heavy Chain|Homo sapiens (9606) QVQLQESGAGLVKPSETLSLSCAVSGGPFSGAYWTWIRQTPGKGLEWIGEAGRSGTTNYNPSLKSRVTISLDTSKSQFSLKLTSVTAADTAVYFCGRRQIMSLSNLYKRPVDSWGRGTPVIVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK |
Light Chain: C
Mutation: NULL
| >7S8H_C|Chain E[auth C]|36.1F Fab Light Chain|Homo sapiens (9606) EIVLTQSPGTLSLSPGERATLSCRASQSVTKNYLAWYQQKPGQAPTLVIYDASTRASGIPDRFIGSGSGTDFTLTISRLEPEDFAVYYCHQYGSSPPYTFGRGTKLEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >7S8H_A|Chain A|Glycoprotein G1|Lassa virus (11622) TSLYKGVYELQTLELNMETLNMTMPLSCTKNNSHHYIMVGNETGLELTLTNTSIINHKFCNLSDAHKKNLYDHALMSIISTFHLSIPNFNQYEAMSCDFNGGKISVQYNLSHSYAGDAANHCGTVANGVLQTFMRMAWGGSYIALDSGRGNWDCIMTSYQYLIIQNTTWEDHCQFSRPSPIGYLCLLSQRTRDIYISRRRR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition B: SER31 GLY32 TYR34 ARG54 SER55 THR57 ILE101 MET102 SER103 LEU104 SER105 ASN106 LEU107 A: ASN74 GLU76 ASN79 LEU84 LYS88 MET96 THR226 TRP227 GLU228 ASP229 HIS230 CYS231 GLN232 ARG235 PRO236 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
