Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6526 |
| PDBID: | 7S2R |
| Chains: | B_A |
| Organism: | Homo sapiens, Camelus bactrianus |
| Method: | XRD |
| Resolution (Å): | 2.49 |
| Reference: | 10.1016/j.cell.2022.02.025 |
| Antibody | |
| Antibody: | gamma-nb6 Nanobody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Cytokine receptor common subunit gamma |
| Antigen mutation: | No |
| Durg Target: | P31785 |
Sequence information
Antibody
Chain: B
Mutation: NULL
| >7S2R_B|Chain B|nanobody gamma-nb6|Camelus bactrianus (9837) QVQLQESGGGSVQAGGSLRLSCAASGYTYRDYYMGWFRQAPGREREGVASIYTRGSREGSTRYSSSVEGRFTITLDTAKNTLYLQMNSLKPEDTAMYYCAADDRTWLPRVQLGGPRENEYNYWGQGTQVTVSSGAPGSGLNDIFEAQKIEWHEHHHHHH |
Antigen
Chain: A
Mutation: NULL
| >7S2R_A|Chain A|Cytokine receptor common subunit gamma|Homo sapiens (9606) ADPLPLPEVQCFVFNVEYMNCTWNSSSEPQPTNLTLHYWYKNSDNDKVQKCSHYLFSEEITSGCQLQKKEIHLYQTFVVQLQDPREPRRQATQMLKLQNLVIPWAPENLTLHKLSESQLELNWNNRFLNHCLEHLVQYRTDWDHSWTEQSVDYRHKFSLPSVDGQKRYTFRVRSRFNPLCGSAQHWSEWSHPIHWGSNTSKENHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition B: TYR32 TYR33 TYR52 ARG54 GLY55 SER56 GLU58 THR105 TRP106 LEU107 PRO108 ARG109 VAL110 GLN111 LEU112 ARG116 ASN118 GLU119 A: VAL67 ASN93 SER94 ASP95 ASN96 LYS119 LYS120 ILE122 HIS123 LEU124 TYR125 GLN126 GLN149 PHE178 LEU179 HIS181 CYS182 PHE227 LEU230 CYS231 GLY232 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
