Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6523 |
| PDBID: | 7RXC |
| Chains: | N_K |
| Organism: | Mus musculus, Vicugna pacos, Escherichia coli, Staphylococcus aureus, Streptococcus sp., Gallus gallus |
| Method: | EM |
| Resolution (Å): | 3.20 |
| Reference: | 10.1073/pnas.2115001118 |
| Antibody | |
| Antibody: | N0 Nanobody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | ER lumen protein-retaining receptor 2 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: N
Mutation: NULL
| >7RXC_N|Chain C[auth N]|Nb_KR|Vicugna pacos (30538) QVQLVESGGGLVQAGGSLRLSCAASGFPVKRWSMTWYRQAPGKEREWVAAIRSAGHWTHYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAVYYCNVKDEGDFSYWYDYWGQGTQVTVSSLEHHHHHH |
Antigen
Chain: K
Mutation: NULL
| >7RXC_K|Chain E[auth K]|ER lumen protein-retaining receptor 2|Gallus gallus (9031) MNIFRLTGDLSHLAAIIILLLKIWKSRSCAGISGKSQLLFALVFTTRYLDLFTSFISLYNTSMKLIYIACSYATVYLIYMKFKATYDGNHDTFRVEFLIVPVGGLSFLVNHDFSPLEILWTFSIYLESVAILPQLFMISKTGEAETITTHYLFFLGLYRALYLVNWIWRYYFEGFFDLIAVVAGVVQTVLYCDFFYLYVTKVLKGKKLSLPAGSGGENLYFQSGGGMDEKTTGWRGGHVVEGLAGELEQLRARLEHHPQGQREP |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition N: VAL29 LYS30 ARG31 SER33 THR35 TYR37 TRP47 ALA50 ARG52 ALA54 GLY55 HIS56 TRP57 HIS59 LYS99 ASP100 GLU101 GLY102 ASP103 PHE104 SER105 TYR106 TRP107 TYR108 ASP109 K: ASN2 ARG5 LEU6 ASP9 ARG47 TYR48 ASP50 THR53 SER54 ILE56 SER57 TYR59 ASN60 MET63 LYS64 TYR67 HIS111 ASP112 LEU116 GLU117 TRP120 TYR162 ARG169 TYR170 TYR171 PHE172 GLU173 GLY174 PHE175 PHE176 ASP177 LEU178 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
