Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6513 |
| PDBID: | 7RCO |
| Chains: | FE_A |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.90 |
| Reference: | 10.1038/s41598-021-01530-w |
| Antibody | |
| Antibody: | 4A11.V2 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | human Transforming growth factor beta-2 |
| Antigen mutation: | No |
| Durg Target: | P61812 |
Sequence information
Antibody
Heavy Chain: F
Mutation: NULL
| >7RCO_F|Chain D, F|4A11.V2 Fab Heavy Chain|Homo sapiens (9606) EQQLVESGGGLVQPGGSLRLSCAVSGFSLSSYTVNWVRQAPGKGLEWIGYISYGGSAYYASWANGRFTISKDSAKNSVYLQMNSLRAEDTAVYFCARHMQVGGAPTGSMAAFDPWGPGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHT |
Light Chain: E
Mutation: NULL
| >7RCO_E|Chain C, E|4A11.V2 Fab Light Chain|Homo sapiens (9606) DAQLTQSPSSLSASVGDRVTITCQSSQSVYNNNYLSWFQQKPGKPPKLLIYGASTLTSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCAGGYSGSSDKYAFGGGTKVEIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >7RCO_A|Chain A, B|Transforming growth factor beta-2|Homo sapiens (9606) ALDAAYCFRNVQDNCCLRPLYIDFKRDLGWKWIHEPKGYNANFCAGACPYLWSSDTQHSRVLSLYNTINPEASASPCCVSQDLEPLTILYYIGKTPKIEQLSNMIVKSCKCS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| E: TYR30 TYR34 TYR94 SER95 GLY96 SER97 LYS100 TYR101 F: THR33 TYR50 SER52 TYR53 GLY54 GLY55 SER56 ALA57 TYR58 TYR59 HIS98 GLN100 VAL101 GLY102 GLY103 GLY107 SER108 A: TYR352 TYR367 ASN368 THR369 ILE370 ASN371 PRO372 GLU373 ALA374 SER375 ALA376 SER377 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
