Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6507 |
| PDBID: | 7R98 |
| Chains: | F_C |
| Organism: | Severe acute respiratory syndrome coronavirus 2, Lama glama |
| Method: | XRD |
| Resolution (Å): | 2.51 |
| Reference: | 10.3389/fimmu.2021.719037 |
| Antibody | |
| Antibody: | B6 Nanobody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | SARS-CoV-2 N protein RBD |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: F
Mutation: NULL
| >7R98_F|Chain D, E, F|Nanobody B6|Lama glama (9844) MAEVQLQASGGGLVQAGDSLRLSCVAVSGRTISTFAMGWFRQAPGKEREFVATINWSGSSARYADPVEGRFTISRDDAKNTVYLEMSSLKPGDSAVYYCASGRYLGGITSYSQGDFAPWGQGTQVTVSSAAALEHHHHHH |
Antigen
Chain: C
Mutation: NULL
| >7R98_C|Chain A, B, C|Nucleoprotein|Severe acute respiratory syndrome coronavirus 2 (2697049) ATASWFTALTQHGKEDLKFPRGQGVPINTNSSPDDQIGYYRRATRRIRGGDGKMKDLSPRWYFYYLGTGPEAGLPYGANKDGIIWVATEGALNTPKDHIGTRNPANNAAIVLQLPQGTTLPKGFYAE |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition F: ALA0 SER26 GLY27 ARG28 THR29 THR32 PHE33 TRP54 SER99 GLY100 ARG101 TYR102 LEU103 GLY104 GLY112 ASP113 PHE114 ALA115 PRO116 C: ARG68 GLY69 PRO80 ASP81 ILE84 PRO122 TYR123 GLY124 ALA134 THR135 GLU136 GLY137 ALA138 LEU139 ASN140 THR141 PRO142 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
