Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6499 |
| PDBID: | 7R24 |
| Chains: | E_A |
| Organism: | Rattus norvegicus, Vicugna pacos |
| Method: | XRD |
| Resolution (Å): | 2.70 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | anti-Arc-2 Nanobody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | human Arc CTD |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: E
Mutation: NULL
| >7R24_E|Chain C[auth E]|anti-Arc nanobody|Vicugna pacos (30538) GSEVQLLESGGGLVQAGDSLRLSCAASGRTFSAYAMGWFRQAPGKEREFVAAISWSGNSTYYADSVKGRFTISRDNAKNTVYLQMNSLKPEDTAIYYCAARKPMYRVDISKGQNYDYWGQGTQVTVSS |
Antigen
Chain: A
Mutation: NULL
| >7R24_A|Chain A|Activity-regulated cytoskeleton-associated protein|Rattus norvegicus (10116) SMELDHMTTGGLHAYPAPRGGPAAKPNVILQIGKCRAEMLEHVRRTHRHLLTEVSKQVERELKGLHRSVGKLENNLDGYVPTGDSQRWKKSIKACLCRCQETIANLERWVKREAAAAAAAFYRLERWADRLESMGGKYPVGSEPARHTVSVGVGGPEPYCQEADGYDYTVSPYAITPPPAAGELPEQESVGAQQYQSWVPGEDGQPSPGVDTQIFEDPREFLSHLEEYLRQVGGSEEYWLSQIQNHMNGPAKKWWEFKQGSVKNWVEFKKEFLQYSEGTLSREAIQRELDLPQKQGEPLDQFLWRKRDLYQTLYVDAEEEEIIQYVVGTLQPKFKRFLRHPLPKTLEQLIQRGMEVQDGLEQAAEPSVTPLPTEDETEALTPALTSESVASDRTQPE |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| E: ARG29 THR30 SER32 ALA33 TYR34 ALA35 PHE49 SER54 TRP55 SER59 TYR61 TYR62 ASP64 ARG101 LYS102 PRO103 MET104 TYR105 ARG106 VAL107 ASP108 ILE109 SER110 LYS111 A: THR212 GLN213 ILE214 PHE215 GLU216 ASP217 PRO218 GLU220 PHE221 SER223 HIS224 LEU225 GLU227 TYR228 GLN231 VAL232 ASN245 HIS246 MET247 ASN248 ALA251 PHE272 TYR275 SER276 LEU280 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
