Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6498 |
| PDBID: | 7R24 |
| Chains: | C_A |
| Organism: | Rattus norvegicus, Vicugna pacos |
| Method: | XRD |
| Resolution (Å): | 2.70 |
| Reference: | Not available or To be published |
| Antibody | |
| Antibody: | anti-Arc-1 Nanobody |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | human Arc CTD |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Chain: C
Mutation: NULL
| >7R24_C|Chain B[auth C]|anti-Arc nanobody|Vicugna pacos (30538) GSEVQLVESGGGLVQAGGSLRLSCAASGRTSGALNVAWYRQATGKEREYVARLWWNDGTTYYSDSVKGRFTISSDNAKKIVYLQMNRLKPDDTAIYYCAVRTPSSQTLYWGQGTQVTVSS |
Antigen
Chain: A
Mutation: NULL
| >7R24_A|Chain A|Activity-regulated cytoskeleton-associated protein|Rattus norvegicus (10116) SMELDHMTTGGLHAYPAPRGGPAAKPNVILQIGKCRAEMLEHVRRTHRHLLTEVSKQVERELKGLHRSVGKLENNLDGYVPTGDSQRWKKSIKACLCRCQETIANLERWVKREAAAAAAAFYRLERWADRLESMGGKYPVGSEPARHTVSVGVGGPEPYCQEADGYDYTVSPYAITPPPAAGELPEQESVGAQQYQSWVPGEDGQPSPGVDTQIFEDPREFLSHLEEYLRQVGGSEEYWLSQIQNHMNGPAKKWWEFKQGSVKNWVEFKKEFLQYSEGTLSREAIQRELDLPQKQGEPLDQFLWRKRDLYQTLYVDAEEEEIIQYVVGTLQPKFKRFLRHPLPKTLEQLIQRGMEVQDGLEQAAEPSVTPLPTEDETEALTPALTSESVASDRTQPE |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| C: LEU34 ASN35 TYR39 ARG47 TYR49 ARG52 TRP54 ASN56 ASP57 THR59 TYR61 LYS67 ARG101 THR102 PRO103 SER104 SER105 GLN106 THR107 LEU108 TRP110 A: ARG282 GLN286 TYR310 THR312 LEU313 TYR314 VAL315 ASP316 ALA317 GLU318 GLU320 GLU321 GLN324 TYR325 GLY328 LYS335 ARG339 HIS340 LEU342 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
