Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6495 |
| PDBID: | 7QVK |
| Chains: | B_A |
| Organism: | Homo sapiens, Camelus bactrianus |
| Method: | XRD |
| Resolution (Å): | 3.10 |
| Reference: | 10.1371/journal.pone.0288259 |
| Antibody | |
| Antibody: | NM-02 VH-sdAb |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Receptor tyrosine-protein kinase erbB-2 (HER-2) |
| Antigen mutation: | No |
| Durg Target: | P04626 |
Sequence information
Antibody
Chain: B
Mutation: NULL
| >7QVK_B|Chain B[auth BBB]|NM-02|Camelus bactrianus (9837) QVQLQESGGGSVQAGETLRLSCTASGFTFDDSDMGWYRQAPGNECELVSSISSDGSTYYADSVKGRFTISQDNAKNTVYLQMNSLKPEDTGVYYCAAEGHRYELGTCAALDYWGRGTQVTVSSGSGHHHHHH |
Antigen
Chain: A
Mutation: NULL
| >7QVK_A|Chain A[auth AAA]|Receptor tyrosine-protein kinase erbB-2|Homo sapiens (9606) TQVCTGTDMKLRLPASPETHLDMLRHLYQGCQVVQGNLELTYLPTNASLSFLQDIQEVQGYVLIAHNQVRQVPLQRLRIVRGTQLFEDNYALAVLDNGDPLNNTTPVTGASPGGLRELQLRSLTEILKGGVLIQRNPQLCYQDTILWKDIFHKNNQLALTLIDTNRSRACHPCSPMCKGSRCWGESSEDCQSLTRTVCAGGCARCKGPLPTDCCHEQCAAGCTGPKHSDCLACLHFNHSGICELHCPALVTYNTDTFESMPNPEGRYTFGASCVTACPYNYLSTDVGSCTLVCPLHNQEVTAEDGTQRCEKCSKPCARVCYGLGMEHLREVRAVTSANIQEFAGCKKIFGSLAFLPESFDGDPASNTAPLQPEQLQVFETLEEITGYLYISAWPDSLPDLSVFQNLQVIRGRILHNGAYSLTLQGLGISWLGLRSLRELGSGLALIHHNTHLCFVHTVPWDQLFRNPHQALLHTANRPEDECVGEGLACHQLCARGHCWGPGPTQCVNCSQFLRGQECVEECRVLQGLPREYVNARHCLPCHPECQPQNGSVTCFGPEADQCVACAHYKDPPFCVARCPSGVKPDLSYMPIWKFPDEEGACQPCPINCTHSCVDLDDKGCPAEQHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| B: GLN3 LEU4 PHE27 HIS100 ARG101 TYR102 GLU103 LEU104 ALA108 ALA109 LEU110 ASP111 TYR112 TRP113 ARG115 A: LYS148 LYS153 LYS178 GLY179 ARG181 GLN191 SER192 LEU193 ARG195 THR196 VAL197 CYS198 ALA199 GLY200 GLY201 CYS205 LYS206 GLY207 PRO208 LEU209 PRO210 THR211 ASP212 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
