Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6478 |
| PDBID: | 8UDG |
| Chains: | MN_B |
| Organism: | Influenza B virus (B/Malaysia/2506/2004), Homo sapiens |
| Method: | EM |
| Resolution (Å): | 4.98 |
| Reference: | 10.1073/pnas.2316964120 |
| Antibody | |
| Antibody: | S1V2-72 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza B virus Malaysia/2506/2004 Victoria hemagglutinin EHA2 |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: M
Mutation: NULL
| >8UDG_M|Chain D[auth H], F[auth M]|S1V2-72 heavy chain|Homo sapiens (9606) QVQLVQSGAELKKPGASVKVSCKASGYTFTGNYIHWMRQVPGQGLEWMGWINPRTGDTHHAQKFQGRVDMTRDTSINTAYLELTRLESDDTALYYCARCVFATSQFDPWGQGTLVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCDK |
Light Chain: N
Mutation: NULL
| >8UDG_N|Chain E[auth L], G[auth N]|S1V2-72 light chain|Homo sapiens (9606) QSALTQPASVSGSPGQSITISCTGTNSDIGSHNLVSWYQQHPGKAPKVMIYDDSKRPSGVSNRFSGSKSGSTASLTISGLQSEDEADYYCCSYAGSSNWVFGGGTKLTLLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: B
Mutation: NULL
| >8UDG_B|Chain A, B, C|Hemagglutinin|Influenza B virus (B/Malaysia/2506/2004) (464417) GYTSHGAHGVAVAADLKSTQEAINKITKNLNSLSELEVKNLQRLSGAMDEIHNEILELDEKVDDLRADTISSQIELAVLLSNEGIINSEDEHLLALERKLKKMLGPSAVDIGNGCFETKHKCNQTCLDRIAAGTFNAGEFSLPTFDSLNITAASLNDDG |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| M: THR28 THR30 GLY31 TYR33 HIS35 TRP50 ASN52 ARG54 THR55 ASP57 THR74 CYS99 VAL100 PHE101 ALA102 THR103 N: SER31 HIS32 LEU34 TYR93 GLY95 SER96 SER97 TRP99 B: VAL100 SER103 ASN104 SER110 GLU111 LEU115 LEU116 GLU119 ARG120 LYS123 VAL131 ASP132 ILE133 GLY134 ASN135 GLY136 CYS137 PHE138 GLU139 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
