Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6466 |
| PDBID: | 8TPA |
| Chains: | DE_C |
| Organism: | Influenza A virus (A/New Caledonia/20/1999(H1N1)), Homo sapiens |
| Method: | EM |
| Resolution (Å): | 3.00 |
| Reference: | 10.1101/2023.08.23.554525 |
| Antibody | |
| Antibody: | 2-2-1G06 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus New Caledonia/20/1999 H1N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: D
Mutation: NULL
| >8TPA_D|Chain B[auth D], F[auth H], J[auth I]|Heavy chain of Fab 2-2-1G06|Homo sapiens (9606) QVQLRESGPGLVKPSQTLSLTCTVSGDSISNGGLYWNWIRQRPGRGLEWIGYIYYNGVTTYNPSLRSRIAISLETAKNQLSLRLSSVSAADTAIYYCAREGWVPDYGGRNYYLDFWGQGTLVTVSS |
Light Chain: E
Mutation: NULL
| >8TPA_E|Chain C[auth E], G[auth J], K[auth L]|Light chain of Fab 2-2-1G06|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCRASHNIQNFLNWYQQKPGKAPKLLIYAASTLQSGVPSRFSGSGSRTDFTLTISSLQPEDFAAYYCQQSYGLPRTFGQGTRLEIK |
Antigen
Chain: C
Mutation: NULL
| >8TPA_C|Chain A, E[auth C], I[auth G]|Hemagglutinin HA1 chain|Influenza A virus (A/New Caledonia/20/1999(H1N1)) (381512) MKAKLLVLLCTFTATYADTICIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDSHNGKLCLLKGIAPLQLGNCSVAGWILGNPECELLISKESWSYIVETPNPENGTCYPGYFADYEELREQLSSVSSFERFEIFPKESSWPNHTVTGVSASCSHNGKSSFYRNLLWLTGKNGLYPNLSKSYVNNKEKEVLVLWGVHHPPNIGNQRALYHTENAYVSVVSSHYSRRFTPEIAKRPKVRDQEGRINYYWTLLEPGDTIIFEANGNLIAPWYAFALSRGFGSGIITSNAPMDECDAKCQTPQGAINSSLPFQNVHPVTIGECPKYVRSAKLRMVTGLRNIPSIQSR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| D: TYR52 ASN54 VAL56 THR57 THR58 TRP97 PRO99 E: ASP1 ILE2 HIS27 TYR92 GLY93 LEU94 PRO95 C: ASP45 SER46 HIS47 ASN48 GLY49 LYS50 PRO91 ASN92 GLU94 THR269 ASN271 PRO273 GLN285 ASN296 VAL297 HIS298 PRO299 TYR308 ARG310 SER311 ALA312 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
