Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6461 |
| PDBID: | 8TP9 |
| Chains: | HL_A |
| Organism: | Influenza A virus (A/Singapore/1/1957(H2N2)), Homo sapiens |
| Method: | EM |
| Resolution (Å): | 3.10 |
| Reference: | 10.1101/2023.08.23.554525 |
| Antibody | |
| Antibody: | 2-2-1G06 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus Singapore/1/1957 H2N2 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >8TP9_H|Chain D, E, H|Heavy chain of Fab 2-2-1G06|Homo sapiens (9606) QVQLRESGPGLVKPSQTLSLTCTVSGDSISNGGLYWNWIRQRPGRGLEWIGYIYYNGVTTYNPSLRSRIAISLETAKNQLSLRLSSVSAADTAIYYCAREGWVPDYGGRNYYLDFWGQGTLVTVSS |
Light Chain: L
Mutation: NULL
| >8TP9_L|Chain F, G, I[auth L]|Light chain of Fab 2-2-1G06|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCRASHNIQNFLNWYQQKPGKAPKLLIYAASTLQSGVPSRFSGSGSRTDFTLTISSLQPEDFAAYYCQQSYGLPRTFGQGTRLEIK |
Antigen
Chain: A
Mutation: NULL
| >8TP9_A|Chain A, B, C|Hemagglutinin|Influenza A virus (A/Singapore/1/1957(H2N2)) (382781) MAIIYLILLFTAVRGDQICIGYHANNSTEKVDTILERNVTVTHAKDILEKTHNGKLCKLNGIPPLELGDCSIAGWLLGNPECDRLLSVPEWSYIMEKENPRDGLCYPGSFNDYEELKHLLSSVKHFEKVKILPKDRWTQHTTTGGSRACAVSGNPSFFRNMVWLTKKGSNYPVAKGSYNNTSGEQMLIIWGVHHPNDETEQRTLYQNVGTYVSVGTSTLNKRSTPDIATRPKVNGQGGRMEFSWTLLDMWDTINFESTGNLIAPEYGFKISKRGSSGIMKTEGTLENCETKCQTPLGAINTTLPFHNVHPLTIGECPKYVKSEKLVLATGLRNVPQIESRGLFGAIAGFIEGGWQGMVDGWYGYHHSNDQGSGYAADKESTQKAFDGITNKVNSVIEKMNTQFEAVGKEFSNLERRLENLNKKMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYDKVRMQLRDNVKELGNGCFEFYHKCDDECMNSVKNGTYDYPKYEEES |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| H: GLY33 TYR52 TYR53 ASN54 VAL56 TRP97 VAL98 PRO99 L: ASP1 ILE2 HIS27 GLN30 ARG68 TYR92 GLY93 LEU94 PRO95 A: LYS45 THR46 HIS47 ASN48 GLY49 LYS50 GLU91 THR270 GLU271 GLY272 GLU275 LEU285 ASN296 VAL297 HIS298 PRO299 TYR308 LYS310 SER311 GLU312 GLU407 ASN408 LYS411 ASP415 LEU418 ASP419 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 5Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 5 Å from any atom.
Interacting residues (Atom distance based)
