Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6460 |
| PDBID: | 8TP7 |
| Chains: | HL_C |
| Organism: | Influenza A virus (A/Singapore/1/1957(H2N2)), Homo sapiens |
| Method: | EM |
| Resolution (Å): | 2.80 |
| Reference: | 10.1101/2023.08.23.554525 |
| Antibody | |
| Antibody: | 4-1-1G03 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus Singapore/1/1957 H2N2 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >8TP7_H|Chain D, E, H|Heavy chain of monoclonal antibody 4-1-1G03|Homo sapiens (9606) QVQLQESGPGLVKTSETLSLTCAVSGGSISGSRYYWAWIRQPPGKGLEWIGNLYYSGTNFYNPSLEGRVTISVDTSKNQVSLKLSSVTAADTAVYFCARHVYYSDTNSYTYFFDYWGQGTLVTVSS |
Light Chain: L
Mutation: NULL
| >8TP7_L|Chain F, G, I[auth L]|Light chain of monoclonal antibody 4-1-1G03|Homo sapiens (9606) ALTQPASVSGSPGQSITISCTGTSSDIGGYNYVSWYQNHPGKAPKLIIYDVSHRPSGVSNRFSGSKSGNTASLSISGLQAEDEADYYCCSFTDNNIPAFGGGTKLTVL |
Antigen
Chain: C
Mutation: NULL
| >8TP7_C|Chain A, B, C|Hemagglutinin|Influenza A virus (A/Singapore/1/1957(H2N2)) (382781) MAIIYLILLFTAVRGDQICIGYHANNSTEKVDTILERNVTVTHAKDILEKTHNGKLCKLNGIPPLELGDCSIAGWLLGNPECDRLLSVPEWSYIMEKENPRDGLCYPGSFNDYEELKHLLSSVKHFEKVKILPKDRWTQHTTTGGSRACAVSGNPSFFRNMVWLTKKGSNYPVAKGSYNNTSGEQMLIIWGVHHPNDETEQRTLYQNVGTYVSVGTSTLNKRSTPDIATRPKVNGQGGRMEFSWTLLDMWDTINFESTGNLIAPEYGFKISKRGSSGIMKTEGTLENCETKCQTPLGAINTTLPFHNVHPLTIGECPKYVKSEKLVLATGLRNVPQIESRGLFGAIAGFIEGGWQGMVDGWYGYHHSNDQGSGYAADKESTQKAFDGITNKVNSVIEKMNTQFEAVGKEFSNLERRLENLNKKMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYDKVRMQLRDNVKELGNGCFEFYHKCDDECMNSVKNGTYDYPKYEEESKLNRNEIKGVKLSSMGVYQILAIYATVAGSLSLAIMMAGISFWMCSNGSLQCRICI |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: SER32 ARG33 TYR52 SER54 GLY55 THR56 PHE58 TYR97 TYR98 L: TYR30 TYR32 PHE91 ASP93 ASN94 ILE95 C: ARG126 TRP127 THR128 GLN129 HIS130 LYS157 GLY158 SER159 ASN160 TYR161 PRO162 VAL163 LYS165 GLY166 SER167 ARG192 GLN196 ASN197 GLY199 TYR201 GLU246 THR248 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
