Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6455 |
| PDBID: | 8TP6 |
| Chains: | HL_A |
| Organism: | Influenza A virus (A/Singapore/1/1957(H2N2)), Homo sapiens |
| Method: | EM |
| Resolution (Å): | 3.10 |
| Reference: | 10.1101/2023.08.23.554525 |
| Antibody | |
| Antibody: | 4-1-1E02 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus Singapore/1/1957 H2N2 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >8TP6_H|Chain B[auth C], E[auth F], H|Heavy chain of 4-1-1E02 Fab|Homo sapiens (9606) QVQLQESGPGLVKPSQTLSLTCTVSGGSISSGNYYWSWIRQPAGEELECLGRIYTTGSTNYSPSLKSRVTISLETSKNQFSLRLNSVTAADTAVYYCARGMDFGPTDAFDIWGQGTMVTVSS |
Light Chain: L
Mutation: NULL
| >8TP6_L|Chain C[auth D], F[auth G], I[auth L]|Light chain of 4-1-1E02 Fab|Homo sapiens (9606) DIQMTQSPSSLSASVGDRVTITCRASQSVSSYLNWYQQRSGKAPRLLIYTVTNFQSGVPSRFSGSGSGTDFTLTISSLQPEDFATYYCQESYTSRLTFGGGTKVEIK |
Antigen
Chain: A
Mutation: NULL
| >8TP6_A|Chain A, D[auth B], G[auth E]|Hemagglutinin|Influenza A virus (A/Singapore/1/1957(H2N2)) (382781) MAIIYLILLFTAVRGDQICIGYHANNSTEKVDTILERNVTVTHAKDILEKTHNGKLCKLNGIPPLELGDCSIAGWLLGNPECDRLLSVPEWSYIMEKENPRDGLCYPGSFNDYEELKHLLSSVKHFEKVKILPKDRWTQHTTTGGSRACAVSGNPSFFRNMVWLTKKGSNYPVAKGSYNNTSGEQMLIIWGVHHPNDETEQRTLYQNVGTYVSVGTSTLNKRSTPDIATRPKVNGQGGRMEFSWTLLDMWDTINFESTGNLIAPEYGFKISKRGSSGIMKTEGTLENCETKCQTPLGAINTTLPFHNVHPLTIGECPKYVKSEKLVLATGLRNVPQIESRGLFGAIAGFIEGGWQGMVDGWYGYHHSNDQGSGYAADKESTQKAFDGITNKVNSVIEKMNTQFEAVGKEFSNLERRLENLNKKMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYDKVRMQLRDNVKELGNGCFEFYHKCDDECMNSVKNGTYDYPKYEE |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: SER30 SER31 GLY32 ASN33 TYR34 TYR52 THR53 THR54 SER56 ARG94 MET96 ASP97 PHE98 GLY99 ASP101 L: SER30 SER31 TYR32 TYR49 THR50 VAL51 THR52 ASN53 PHE54 GLN55 SER91 TYR92 THR93 SER94 A: TYR98 THR131 THR133 GLY134 GLY135 SER136 ARG137 GLY143 ASN144 PRO145 TRP153 THR155 LYS156 LYS157 GLY158 SER159 ASN186 ASP187 THR189 GLU190 THR193 LEU194 THR219 LYS222 GLY225 GLN226 GLY227 GLY228 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
