Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6452 |
| PDBID: | 8TP5 |
| Chains: | EF_C |
| Organism: | Influenza A virus (A/New Caledonia/20/1999(H1N1)), Homo sapiens |
| Method: | EM |
| Resolution (Å): | 2.90 |
| Reference: | 10.1101/2023.08.23.554525 |
| Antibody | |
| Antibody: | 1-1-1E04 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus New Caledonia/20/1999 H1N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: E
Mutation: NULL
| >8TP5_E|Chain E, H, J|Heavy chain of Fab 1-1-1E04|Homo sapiens (9606) QVQLVQSGAQLRKPGSSVTVSCKASGDTFNSYSIHWVRQAPGQGLEWMGRIIPVFGMTHYAQRFRGRITVSADKSTRTAYMELTSLTSADTAMYYCARDGGDKFHSSGHFETNQGYFDHWGQGALVTVSS |
Light Chain: F
Mutation: NULL
| >8TP5_F|Chain F, K, L|Light chain of Fab 1-1-1E04|Homo sapiens (9606) QSVLTQPPSVSGAPGQRVTVSCTGSSSNLGATYEVHWYQQFPGTAPKLLIYGSTNRPSGVPERFSGSKSGTSASLTITGLQAEDEADYYCQSYDTSLRGFYVFGTGTKVTVL |
Antigen
Chain: C
Mutation: NULL
| >8TP5_C|Chain A, C, G|Hemagglutinin HA1 chain|Influenza A virus (A/New Caledonia/20/1999(H1N1)) (381512) DTICIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDSHNGKLCLLKGIAPLQLGNCSVAGWILGNPECELLISKESWSYIVETPNPENGTCYPGYFADYEELREQLSSVSSFERFEIFPKESSWPNHTVTGVSASCSHNGKSSFYRNLLWLTGKNGLYPNLSKSYVNNKEKEVLVLWGVHHPPNIGNQRALYHTENAYVSVVSSHYSRRFTPEIAKRPKVRDQEGRINYYWTLLEPGDTIIFEANGNLIAPWYAFALSRGFGSGIITSNAPMDECDAKCQTPQGAINSSLPFQNVHPVTIGECPKYVRSAKLRMVTGLRNIPS |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition E: MET56 HIS58 LYS99 F: THR30 TYR31 GLU32 GLY50 THR52 ASN53 TYR91 THR93 C: THR131 VAL132 THR133 GLY134 VAL135 SER136 ALA137 ASN142 GLY143 LYS144 SER145 TRP153 THR155 LYS157 ASN158 PRO186 ASN187 GLY189 ASN190 ALA193 LEU194 LYS219 LYS222 ASP225 GLN226 GLU227 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
