Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6451 |
| PDBID: | 8TP4 |
| Chains: | HL_C |
| Organism: | Influenza A virus (A/Singapore/1/1957(H2N2)), Homo sapiens |
| Method: | EM |
| Resolution (Å): | 3.30 |
| Reference: | 10.1101/2023.08.23.554525 |
| Antibody | |
| Antibody: | 1-1-1E04 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus Singapore/1/1957 H2N2 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >8TP4_H|Chain B[auth H]|Heavy chain of Fab 1-1-1E04|Homo sapiens (9606) QVQLVQSGAQLRKPGSSVTVSCKASGDTFNSYSIHWVRQAPGQGLEWMGRIIPVFGMTHYAQRFRGRITVSADKSTRTAYMELTSLTSADTAMYYCARDGGDKFHSSGHFETNQGYFDHWGQGALVTVSS |
Light Chain: L
Mutation: NULL
| >8TP4_L|Chain C[auth L]|Light chain of Fab 1-1-1E04|Homo sapiens (9606) QSVLTQPPSVSGAPGQRVTVSCTGSSSNLGATYEVHWYQQFPGTAPKLLIYGSTNRPSGVPERFSGSKSGTSASLTITGLQAEDEADYYCQSYDTSLRGFYVFGTGTKVTVLGQPKANPTVTLFP |
Antigen
Chain: C
Mutation: NULL
| >8TP4_C|Chain A, D[auth B], E[auth C]|Hemagglutinin|Influenza A virus (A/Singapore/1/1957(H2N2)) (382781) MAIIYLILLFTAVRGDQICIGYHANNSTEKVDTILERNVTVTHAKDILEKTHNGKLCKLNGIPPLELGDCSIAGWLLGNPECDRLLSVPEWSYIMEKENPRDGLCYPGSFNDYEELKHLLSSVKHFEKVKILPKDRWTQHTTTGGSRACAVSGNPSFFRNMVWLTKKGSNYPVAKGSYNNTSGEQMLIIWGVHHPNDETEQRTLYQNVGTYVSVGTSTLNKRSTPDIATRPKVNGQGGRMEFSWTLLDMWDTINFESTGNLIAPEYGFKISKRGSSGIMKTEGTLENCETKCQTPLGAINTTLPFHNVHPLTIGECPKYVKSEKLVLATGLRNVPQIESRGLFGAIAGFIEGGWQGMVDGWYGYHHSNDQGSGYAADKESTQKAFDGITNKVNSVIEKMNTQFEAVGKEFSNLERRLENLNKKMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYDKVRMQLRDNVKELGNGCFEFYHKCDDECMNSVKNGTYDYPKYEEES |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: ARG50 PHE55 MET56 HIS58 LYS99 L: THR30 TYR31 GLU32 GLY50 ASN53 TYR91 THR93 C: TYR98 ASP125 HIS130 THR131 THR132 THR133 GLY134 GLY135 SER136 ARG137 SER142 GLY143 ASN144 PRO145 TRP153 THR155 LYS157 GLY158 ASN186 THR189 GLU190 THR193 LEU194 LYS222 GLY225 GLN226 GLY227 GLY228 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
