Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6450 |
| PDBID: | 8TP3 |
| Chains: | HL_C |
| Organism: | Influenza A virus (A/New Caledonia/20/1999(H1N1)), Homo sapiens |
| Method: | EM |
| Resolution (Å): | 3.60 |
| Reference: | 10.1101/2023.08.23.554525 |
| Antibody | |
| Antibody: | 1-1-1F05 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus New Caledonia/20/1999 H1N1 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >8TP3_H|Chain G[auth H]|Heavy chain of Fab 1-1-1F05|Homo sapiens (9606) QVQLQESGPGLVKPSATLSLTCTLSGGSLSTHYWSWIRQPPGKGLEYIGNIHYSGSTNYNPSLRSRVTISVGTSKNQFSLKLTSVTAADTAVYYCARDAPYSDFLSGVETGWFDPWGQGTLVIVSS |
Light Chain: L
Mutation: NULL
| >8TP3_L|Chain H[auth L]|Light chain of Fab 1-1-1F05|Homo sapiens (9606) EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTDFTLTISSLQSEDFAVYSCQQYNNWPWTFGQGTKVEIK |
Antigen
Chain: C
Mutation: NULL
| >8TP3_C|Chain A, C, E[auth G]|Hemagglutinin HA1 chain|Influenza A virus (A/New Caledonia/20/1999(H1N1)) (381512) MKAKLLVLLCTFTATYADTICIGYHANNSTDTVDTVLEKNVTVTHSVNLLEDSHNGKLCLLKGIAPLQLGNCSVAGWILGNPECELLISKESWSYIVETPNPENGTCYPGYFADYEELREQLSSVSSFERFEIFPKESSWPNHTVTGVSASCSHNGKSSFYRNLLWLTGKNGLYPNLSKSYVNNKEKEVLVLWGVHHPPNIGNQRALYHTENAYVSVVSSHYSRRFTPEIAKRPKVRDQEGRINYYWTLLEPGDTIIFEANGNLIAPWYAFALSRGFGSGIITSNAPMDECDAKCQTPQGAINSSLPFQNVHPVTIGECPKYVRSAKLRMVTGLRNIPSIQSR |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: SER30 THR31 TYR33 HIS52 TYR53 SER54 SER56 ASN58 TYR98 L: ASN32 TYR91 ASN92 ASN93 TRP94 TRP96 C: THR131 THR133 GLY134 VAL135 SER136 ALA137 LYS144 SER145 TRP153 THR155 GLY156 LYS157 ASN158 GLY159 ASN190 ALA193 LEU194 HIS196 LYS222 ASP225 GLN226 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
