Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6449 |
| PDBID: | 8TP2 |
| Chains: | HL_C |
| Organism: | Homo sapiens |
| Method: | EM |
| Resolution (Å): | 3.10 |
| Reference: | 10.1101/2023.08.23.554525 |
| Antibody | |
| Antibody: | 1-1-1F05 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Influenza A virus Singapore/1/1957 H2N2 hemagglutinin |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >8TP2_H|Chain A[auth H]|Heavy chain of Fab 1-1-1F05|Homo sapiens (9606) QVQLQESGPGLVKPSATLSLTCTLSGGSLSTHYWSWIRQPPGKGLEYIGNIHYSGSTNYNPSLRSRVTISVGTSKNQFSLKLTSVTAADTAVYYCARDAPYSDFLSGVETGWFDPWGQGTLVIVSS |
Light Chain: L
Mutation: NULL
| >8TP2_L|Chain B[auth L]|Light chain of Fab 1-1-1F05|Homo sapiens (9606) EIVMTQSPATLSVSPGERATLSCRASQSVSSNLAWYQQKPGQAPRLLIYGASTRATGIPARFSGSGSGTDFTLTISSLQSEDFAVYSCQQYNNWPWTFGQGTKVEIK |
Antigen
Chain: C
Mutation: NULL
| >8TP2_C|Chain C[auth A], D[auth B], E[auth C]|Hemagglutinin|Homo sapiens (9606) MAIIYLILLFTAVRGDQICIGYHANNSTEKVDTILERNVTVTHAKDILEKTHNGKLCKLNGIPPLELGDCSIAGWLLGNPECDRLLSVPEWSYIMEKENPRDGLCYPGSFNDYEELKHLLSSVKHFEKVKILPKDRWTQHTTTGGSRACAVSGNPSFFRNMVWLTKKGSNYPVAKGSYNNTSGEQMLIIWGVHHPNDETEQRTLYQNVGTYVSVGTSTLNKRSTPDIATRPKVNGQGGRMEFSWTLLDMWDTINFESTGNLIAPEYGFKISKRGSSGIMKTEGTLENCETKCQTPLGAINTTLPFHNVHPLTIGECPKYVKSEKLVLATGLRNVPQIESRGLFGAIAGFIEGGWQGMVDGWYGYHHSNDQGSGYAADKESTQKAFDGITNKVNSVIEKMNTQFEAVGKEFSNLERRLENLNKKMEDGFLDVWTYNAELLVLMENERTLDFHDSNVKNLYDKVRMQLRDNVKELGNGCFEFYHKCDDECMNSVKNGTYDYPKYEEES |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: SER30 THR31 TYR33 HIS52 SER54 SER56 THR57 ASN58 TYR98 L: SER30 ASN32 TYR91 ASN92 ASN93 TRP94 TRP96 C: TYR98 THR131 THR133 GLY134 GLY135 SER136 ARG137 ALA138 ASN144 PRO145 TRP153 THR155 LYS156 LYS157 GLY158 SER159 ASP187 THR189 GLU190 ARG192 THR193 LEU194 GLN196 ASN224 GLY225 GLN226 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
