Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6446 |
| PDBID: | 8TFR |
| Chains: | AB_C |
| Organism: | Streptococcus sp. 'group G, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.99 |
| Reference: | 10.1021/acschemneuro.3c00455 |
| Antibody | |
| Antibody: | C10-S66K Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Streptococcus sp. 'group G immunoglobulin G-binding protein G |
| Antigen mutation: | No |
| Durg Target: | P19909 |
Sequence information
Antibody
Heavy Chain: A
Mutation: NULL
| >8TFR_A|Chain B[auth A]|Heavy chain from Fab of C10_S66K antibody|Homo sapiens (9606) QVQLQESGPGLVKPSGTLSLTCTVSGGFISSRNWWSWVRQPPGKGLEWIGEVYHTGITNYNPSLKSRVTISVDKSKNQFSLKLSSVTAADTAVYYCAREVVGPTTGYFDLWGRGTLVTISSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSC |
Light Chain: B
Mutation: NULL
| >8TFR_B|Chain C[auth B]|Light chain from Fab of C10_S66K antibody|Homo sapiens (9606) SYELTQPPSVSVSPGQTARITCSGDTLPKRSGYWYQQKPDQAPLLVINKDTERPSGIPERFSGSKSGTTVTLTISGVQAEDEADYYCQSADSSFTYPSFGGGTKLTVLGQPKAAPSVTLFPPSSEELQANKATLVCLISDFYPGAVTVAWKADSSPVKAGVETTTPSKQSNNKYAASSYLSLTPEQWKSHRSYSCQVTHEGSTVEKTVAPTECS |
Antigen
Chain: C
Mutation: NULL
| >8TFR_C|Chain A[auth C]|Immunoglobulin G-binding protein G|Streptococcus sp. group G (1320) MTPAVTTYKLVINGKTLKGETTTKAVDAETAEKAFKQYANDNGVDGVWTYDDATKTFTVTEHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition A: THR116 LYS117 GLY118 PRO119 SER120 VAL121 PHE122 PRO123 SER203 ASN204 THR205 LYS206 VAL207 ASP208 LYS209 LYS210 GLU212 B: GLU123 GLN126 ALA127 C: ILE12 THR16 LEU17 LYS18 GLY19 GLU20 THR21 THR22 LYS24 GLN37 TYR38 ASN40 ASP41 ASN42 GLY43 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
