Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6443 |
| PDBID: | 8T7A |
| Chains: | DE_a |
| Organism: | Respiratory syncytial virus A2, Homo sapiens |
| Method: | EM |
| Resolution (Å): | 2.80 |
| Reference: | 10.1128/jvi.00929-23 |
| Antibody | |
| Antibody: | 2.4K Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Respiratory syncytial virus A2 fusion glycoprotein F1 |
| Antigen mutation: | No |
| Durg Target: | P03420; P11209; P13843; |
Sequence information
Antibody
Heavy Chain: D
Mutation: NULL
| >8T7A_D|Chain G[auth D], I[auth F], K[auth H]|2.4K Fab Heavy Chain|Homo sapiens (9606) QVQLVQSGGEVKKPGASVKVSCKASGYTFTYYGISWVRQAPGQGLEWMGWISAYNGNTNYEQKFQGRVTMTTDTSTGTAYMELRSLTSDDTAVYYCARDRIVVVTAANYYGLDVWGQGTTVTVSS |
Light Chain: E
Mutation: NULL
| >8T7A_E|Chain H[auth E], J[auth G], L[auth I]|2.4K Fab Light Chain|Homo sapiens (9606) DIQLTQSPDSLAVSLGERATINCKSSQSVLYRPNNKNFLAWYQQKPGQPPKLLIYWASTRQSGVPDRFSGSGSGTDFTLTISSLQAEDVAVYYCQQYHTTPLTFGGGTKVDIK |
Antigen
Chain: a
Mutation: NULL
| >8T7A_a|Chain B[auth a], D[auth b], F[auth c]|Fusion glycoprotein F1|Respiratory syncytial virus (1972429) FLGFLLGVGSAIASGVAVSKVLHLEGEVNKIKSALLSTNKAVVSLSNGVSVLTSKVLDLKNYIDKQLLPIVNKQSCSIPNIETVIEFQQKNNRLLEITREFSVNAGVTTPVSTYMLTNSELLSLINDMPITNDQKKLMSNNVQIVRQQSYSIMSIIKEEVLAYVVQLPLYGVIDTPCWKLHTSPLCTTNTKEGSNICLTRTDRGWYCDNAGSVSFFPQAETCKVQSNRVFCDTMNSLTLPSEVNLCNVDIFNPKYDCKIMTSKTDVSSSVITSLGAIVSCYGKTKCTASNKNRGIIKTFSNGCDYVSNKGVDTVSVGNTLYYVNKQEGKSLYVKGEPIINFYDPLVFPSDEFDASISQVNEKINQSLAFIRKSDELLGSGYIPEAPRDGQAYVRKDGEWVLLSTFLGRSLEVLFQGPGHHHHHHHHSAWSHPQFEK |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition D: THR28 THR30 TYR31 TYR32 TYR53 ILE97 VAL99 E: PRO27 ASN28 LYS30 a: ASP385 ILE386 PHE387 PRO389 GLU472 ILE474 ASN476 PHE477 TYR478 ASP479 PRO480 LEU481 VAL482 ASN496 ILE499 ASN500 LEU503 PHE505 ILE506 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
