Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6441 |
| PDBID: | 8SZY |
| Chains: | HL_T |
| Organism: | Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.31 |
| Reference: | 10.1080/19420862.2023.2253788 |
| Antibody | |
| Antibody: | BMS-986207 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | Renvistobart(Phase-II) |
| Antigen | |
| Antigen: | Human T-cell immunoreceptor with Ig and ITIM domains (TIGIT) |
| Antigen mutation: | Yes |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >8SZY_H|Chain C[auth H], H[auth I]|BMS-986207 Fab Heavy Chain|Homo sapiens (9606) QVHLQESGPGLVKPSETLSLTCTVSGGSVSSGIYYWSWIRQPPGKGLEWIGYIYYSGSTNYNPSLKSRVTISVDTSKNQFSLKLSSVTAADTAVYYCARDYYVSGNYYNVDYYFFGVDVWGQGTTVTVSSASTKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKRVEPKSCGGHHHHHH |
Light Chain: L
Mutation: NULL
| >8SZY_L|Chain D[auth L], I[auth M]|BMS-986207 light chain|Homo sapiens (9606) EIVLTQSPATLSLSPGERATLSCRASQSVSSYLAWYQQKPGQAPRLLIYDASNRATGIPARFSGSGSGTDFTLTISSLEPEDFAVYYCQQRSNWPPLFTFGPGTKVDIKRTVAAPSVFIFPPSDEQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: T
Mutation: C47S
| >8SZY_T|Chain E[auth T], J[auth U]|T-cell immunoreceptor with Ig and ITIM domains|Homo sapiens (9606) MTGTIETTGNISAEKGGSIILQCHLSSTTAQVTQVNWEQQDQLLAISNADLGWHISPSFKDRVAPGPGLGLTLQSLTVNDTGEYFCIYHTYPDGTYTGRIFLEVLEGGHHHHHH |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: GLY26 GLY27 SER28 SER31 GLY32 ILE33 TYR34 ARG94 TYR96 ASP101 L: SER31 TYR32 LEU46 TYR49 ASP50 ASN53 ARG54 ALA55 THR56 T: THR33 GLN34 ASN36 GLU38 GLN39 GLN40 ASP41 GLN42 LEU43 ILE46 ASN48 ALA49 ASP50 LEU51 GLY52 TRP53 HIS54 SER56 PRO57 SER58 LYS60 HIS89 TYR91 PRO92 ASP93 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
