Details
Structure visualisation
Entry information
| Complex | |
| AACDB_ID: | 6429 |
| PDBID: | 8SLB |
| Chains: | HL_A |
| Organism: | Thermotoga maritima MSB8, Homo sapiens |
| Method: | XRD |
| Resolution (Å): | 2.04 |
| Reference: | 10.1016/j.jmb.2023.168192 |
| Antibody | |
| Antibody: | C12 Fab |
| Antibody mutation: | No |
| INN (Clinical Trial): | |
| Antigen | |
| Antigen: | Thermotoga maritima N-terminal cytosolic sensor domain of CorA (CorANTD) |
| Antigen mutation: | No |
| Durg Target: | |
Sequence information
Antibody
Heavy Chain: H
Mutation: NULL
| >8SLB_H|Chain B[auth H]|sAB C12 Heavy Chain|Homo sapiens (9606) EISEVQLVESGGGLVQPGGSLRLSCAASGFNIYYSSIHWVRQAPGKGLEWVASIYSYSGYTSYADSVKGRFTISADTSKNTAYLQMNSLRAEDTAVYYCARSFYVFKRGTKYPYYNYPAMDYWGQGTLVTVFNQIKGPSVFPLAPSSKSTSGGTAALGCLVKDYFPEPVTVSWNSGALTSGVHTFPAVLQSSGLYSLSSVVTVPSSSLGTQTYICNVNHKPSNTKVDKKVEPKSCDKTHT |
Light Chain: L
Mutation: NULL
| >8SLB_L|Chain C[auth L]|sAB C12 Light Chain|Homo sapiens (9606) SDIQMTQSPSSLSASVGDRVTITCRASQSVSSAVAWYQQKPGKAPKLLIYSASSLYSGVPSRFSGSRSGTDFTLTISSLQPEDFATYYCQQSYYKPITFGQGTKVEIKRTVAAPSVFIFPPSDSQLKSGTASVVCLLNNFYPREAKVQWKVDNALQSGNSQESVTEQDSKDSTYSLSSTLTLSKADYEKHKVYACEVTHQGLSSPVTKSFNRGEC |
Antigen
Chain: A
Mutation: NULL
| >8SLB_A|Chain A|Cobalt/magnesium transport protein CorA|Thermotoga maritima MSB8 (243274) MGSSHHHHHHSSGRENLYFQGHMEEKRLSAKKGLPPGTLVYTGKYREDFEIEVMNYSIEEFREFKTTDVESVLPFRDSSTPTWINITGIHRTDVVQRVGEFFGIHPLVLEDILNVHQRPKVEFFENYVFIVLKMFTYDKNLHELESEQVSLILTKNCVLMFQEKIGDVFDPVRERIRYNRGIIRKKRADYLLYSLIDALVDDYFVLLEKIDDEIDVLEEEVLERPEKETVQRTHQLKRNLVELRKTIWPLREVLSSLYRDVPPLIEKETVPYFRDVYDHTIQIADTVE |
Interaction
1、Solvent accessible surface areas (SASA) were calculated (Naccess V2.1.1) for each residue in antibody and antigen, respectively. The residues with SASA loss in binding of more than 1Å2 were classified as interacting residues.
Interacting residues (ΔSASA based)
| Chain residues position delta_SASA
: residuesposition H: TYR34 SER53 TYR55 TYR57 SER58 TYR60 SER62 LYS68 TYR104 PHE106 ARG108 GLY109 THR110 LYS111 TYR112 PRO113 TYR115 ASN116 TYR117 PRO118 L: SER1 ILE3 GLN28 SER29 SER31 ARG67 TYR93 TYR94 LYS95 PRO96 A: LEU12 PRO13 PRO14 GLY15 THR16 LEU17 VAL18 GLU48 ARG54 ASP55 THR70 ASP71 GLN74 ARG75 GLU78 PHE79 PHE80 GLY81 ILE82 HIS83 PRO84 LEU85 VAL86 GLU88 ASP89 LYS98 VAL99 GLU100 PHE101 PHE102 GLU103 ASN104 TYR105 LYS133 SER234 ARG237 ASP238 PRO240 |
2、We defined interacting paratope-epitope residues by a distance cutoff of < 6 Å . Two amino acids are considered as interacting residues if they have at least one atom within a distance of 6 Å from any atom.
Interacting residues (Atom distance based)
